Mouse Anti-NONO Recombinant Antibody (A1383) (CBMAB-AP12675LY)

Name: Mouse Anti-NONO Recombinant Antibody (A1383)
SKU: CBMAB-AP12675LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A1383

Application

ELISA, WB

Immunogen

Fusion Protein of NONO

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Non-POU Domain Containing Octamer Binding

Introduction

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

Entrez Gene ID

Human	4841
Mouse	53610
Rat	317259

UniProt ID

Human	Q15233
Mouse	Q99K48
Rat	Q5FVM4

Alternative Names

Non-POU Domain Containing Octamer Binding; Protein Phosphatase 1, Regulatory Subunit 114; DNA-Binding P52/P100 Complex, 52 KDa Subunit; 54 KDa Nuclear RNA- And DNA-Binding Protein; 55 KDa Nuclear Protein; P54(Nrb); P54NRB; NMT55; NRB54; Non-Pou Domain-Containing Octamer (ATGCAAAT) Binding Protein;

Function

E-AB-27748

Biological Process

Activation of innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Circadian rhythmISS:UniProtKB
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of circadian rhythmISS:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
RNA splicingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Nucleus, nucleolus
Nucleus speckle
Chromosome
Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic 34 (MRXS34):
A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

PTM

The N-terminus is blocked.

Lone, B. A., Siraj, F., Sharma, I., Ahmad, F., Nagar, P., & Pokharel, Y. R. (2022). Non-POU Domain-Containing Octamer-Binding (NONO) Protein Stability Regulated by PIN1 is Crucial for Breast Cancer Tumorigenicity Via the MAPK/β-Catenin Pathway.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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