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Mouse Anti-NOP2 Recombinant Antibody (E-7) (CBMAB-N2933-WJ)

This product is a Mouse antibody that recognizes NOP2. The antibody E-7 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NOP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
E-7
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NOP2 Nucleolar Protein
Introduction
Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Entrez Gene ID
4839
UniProt ID
P46087
Alternative Names
NOP2 Nucleolar Protein; Proliferation-Associated Nucleolar Protein P120; Proliferating-Cell Nucleolar Antigen P120; Nucleolar Protein 1, 120kDa; Nucleolar Protein 2 Homolog; NSUN1; NOL1; Probable 28S RRNA (Cytosine(4447)-C(5))-Methyltransferase; Putative Ribosomal RNA Methyltransferase NOP2; NOP2 Nucleolar Protein Homolog (Yeast); NOL1/NOP2/Sun Domain Family, Member 1;
Function
Involved in ribosomal large subunit assembly (PubMed:24120868).
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Biological Process
Maturation of LSU-rRNAManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:GO_Central
Regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit assemblyManual Assertion Based On ExperimentIMP:UniProtKB
RNA methylationManual Assertion Based On ExperimentIBA:GO_Central
rRNA base methylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nucleolus
PTM
Citrullinated by PADI4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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