NOP2

Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).

Full Name

NOP2 Nucleolar Protein

Function

Involved in ribosomal large subunit assembly (PubMed:24120868).
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).

Biological Process

Maturation of LSU-rRNAManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:GO_Central
Regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit assemblyManual Assertion Based On ExperimentIMP:UniProtKB
RNA methylationManual Assertion Based On ExperimentIBA:GO_Central
rRNA base methylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nucleolus

PTM

Citrullinated by PADI4.