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Mouse Anti-NOS1AP Recombinant Antibody (3B11) (CBMAB-N2978-WJ)

This product is a Mouse antibody that recognizes NOS1AP. The antibody 3B11 can be used for immunoassay techniques such as: ELISA.
See all NOS1AP antibodies
Published Data
Fig.1 Representative western blots and quantifications of CAPON expression.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B11
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nitric oxide synthase 1 (neuronal) adaptor protein
Introduction
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Entrez Gene ID
9722
UniProt ID
O75052
Alternative Names
Nitric Oxide Synthase 1 Adaptor Protein; C-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein; Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein; CAPON; Ligand Of Neuronal Nitric Oxide Synthase With Carboxyl-Terminal PDZ Domain; C-Terminal PDZ Domain Ligand Of Neuronal Nitric Oxide Synthase (CAPON);
Function
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).
In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862).
Biological Process
Positive regulation of delayed rectifier potassium channel activityBy SimilarityISS:BHF-UCL
Positive regulation of gene expressionBy SimilarityISS:BHF-UCL
Positive regulation of nitric oxide biosynthetic processBy SimilarityISS:BHF-UCL
Positive regulation of nitric oxide mediated signal transductionBy SimilarityISS:BHF-UCL
Positive regulation of nitric-oxide synthase activityBy SimilarityISS:BHF-UCL
Positive regulation of peptidyl-cysteine S-nitrosylationBy SimilarityISS:BHF-UCL
Positive regulation of potassium ion transmembrane transportBy SimilarityISS:BHF-UCL
Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationBy SimilarityISS:BHF-UCL
Postsynaptic actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:SynGO
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channelBy SimilarityISS:BHF-UCL
Regulation of cardiac muscle cell action potentialBy SimilarityISS:BHF-UCL
Regulation of heart rate by chemical signalManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of high voltage-gated calcium channel activityBy SimilarityISS:BHF-UCL
Regulation of nitric oxide biosynthetic process1 PublicationNAS:DFLAT
Regulation of nitric-oxide synthase activity1 PublicationNAS:DFLAT
Regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell projection, filopodium
Cell projection, podosome
Involvement in disease
Nephrotic syndrome 22 (NPHS22):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form that progresses to end-stage renal failure. NPHS22 is an autosomal recessive, steroid-resistant form characterized by onset of progressive kidney dysfunction in infancy.

Smith, A., Auer, D., Johnson, M., Sanchez, E., Ross, H., Ward, C., ... & Kapoor, A. (2023). Cardiac muscle–restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features. G3: Genes, Genomes, Genetics, 13(11), jkad208.

Matiiv, A. B., Moskalenko, S. E., Sergeeva, O. S., Zhouravleva, G. A., & Bondarev, S. A. (2022). NOS1AP Interacts with α-synuclein and aggregates in yeast and mammalian cells. International Journal of Molecular Sciences, 23(16), 9102.

Saygılı, A., & Erbaş, O. (2022). Association of NOS1AP Variants in Schizophrenia. Journal of Experimental and Basic Medical Sciences, 3(1), 084-089.

Cappelli, S., Spalloni, A., Feiguin, F., Visani, G., Šušnjar, U., Brown, A. L., ... & Buratti, E. (2022). NOS1AP is a novel molecular target and critical factor in TDP-43 pathology. Brain Communications, 4(5), fcac242.

Ronchi, C., Bernardi, J., Mura, M., Stefanello, M., Badone, B., Rocchetti, M., ... & Zaza, A. (2021). NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis. Cardiovascular research, 117(2), 472-483.

Majmundar, A. J., Buerger, F., Forbes, T. A., Klämbt, V., Schneider, R., Deutsch, K., ... & Hildebrandt, F. (2021). Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice. Science Advances, 7(1), eabe1386.

Freudenberg, F., Candemir, E., Chen, X., Li, L. L., Esen-Sehir, D., Schenk, N., ... & Reif, A. (2021). Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. EBioMedicine, 71.

Wang, T., Song, J. F., Zhou, X. Y., Li, C. L., Yin, X. X., & Lu, Q. (2021). PPARD rs2016520 (T/C) and NOS1AP rs12742393 (A/C) polymorphisms affect therapeutic efficacy of nateglinide in Chinese patients with type 2 diabetes mellitus. BMC Medical Genomics, 14(1), 1-8.

Wang, Q., Liu, G., Li, J., Zhang, M., Chen, H., Chen, C., ... & Zhang, N. (2020). Effects of interaction of NOS1AP gene polymorphisms and childhood abuse on paranoid personality disorder features among male violent offenders in China. Journal of Psychiatric Research, 130, 180-186.

Zang, X., Li, S., Zhao, Y., Chen, K., Wang, X., Song, W., ... & Gao, C. (2019). Systematic meta-analysis of the association between a common NOS1AP genetic polymorphism, the QTc interval, and sudden death. International Heart Journal, 60(5), 1083-1090.

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For research use only. Not intended for any clinical use.

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