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Rabbit Anti-NR1D1 (phospho S59) Recombinant Antibody (BA0176) (CBMAB-0544CQ)

This product is a rabbit antibody that recognizes NR1D1 (phospho S59). The antibody BA0176 can be used for immunoassay techniques such as: WB.
See all NR1D1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0176
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human NR1D1 aa 50-150 (phospho S59)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. There are two types, Rev-Erbalpha and Rev-Erbbeta. They are important in the regulation of circadian rhythm, as well as lipid homeostasis and lipid metabolism
Entrez Gene ID
9572
UniProt ID
P20393
Alternative Names
EAR1; hRev; THRA1; THRAL; ear-1

Ka, N. L., Park, M. K., Kim, S. S., Jeon, Y., Hwang, S., Kim, S. M., ... & Lee, M. O. (2023). NR1D1 stimulates antitumor immune responses in breast cancer by activating cGAS-STING signaling. Cancer Research, 83(18), 3045-3058.

Zhang-Sun, Z. Y., Xu, X. Z., Escames, G., Lei, W. R., Zhao, L., Zhou, Y. Z., ... & Yang, Y. (2023). Targeting NR1D1 in organ injury: challenges and prospects. Military Medical Research, 10(1), 62.

Yang, Y., Bai, Y., Wang, X., Guo, Y., Yu, Z., Feng, D., ... & Han, P. (2023, July). Clock gene NR1D1 might be a novel target for the treatment of bladder cancer. In Urologic Oncology: Seminars and Original Investigations (Vol. 41, No. 7, pp. 327-e9). Elsevier.

Noh, S. G., Jung, H. J., Kim, S., Arulkumar, R., Kim, D. H., Park, D., & Chung, H. Y. (2022). Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging. International Journal of Molecular Sciences, 23(17), 10032.

Wu, Z., Liao, F., Luo, G., Qian, Y., He, X., Xu, W., ... & Pu, J. (2021). NR1D1 deletion induces rupture-prone vulnerable plaques by regulating macrophage pyroptosis via the NF-κB/NLRP3 inflammasome pathway. Oxidative medicine and cellular longevity, 2021.

Hunter, A. L., Pelekanou, C. E., Barron, N. J., Northeast, R. C., Grudzien, M., Adamson, A. D., ... & Bechtold, D. A. (2021). Adipocyte NR1D1 dictates adipose tissue expansion during obesity. Elife, 10, e63324.

Wang, H., & Fu, Y. (2021). NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway. BMC cancer, 21(1), 1-12.

Liu, H., Zhu, Y., Gao, Y., Qi, D., Zhao, L., Zhao, L., ... & Xiao, J. (2020). NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis. Cell death & disease, 11(2), 129.

Murayama, Y., Yahagi, N., Takeuchi, Y., Aita, Y., Mehrazad Saber, Z., Wada, N., ... & Shimano, H. (2019). Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex. FEBS letters, 593(4), 423-432.

Ferder, I. C., Fung, L., Ohguchi, Y., Zhang, X., Lassen, K. G., Capen, D., ... & Wang, N. (2019). Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice. PLoS genetics, 15(5), e1008084.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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