Rabbit Anti-NR1D1 (phospho S59) Recombinant Antibody (BA0176) (CBMAB-0544CQ)

Name: Rabbit Anti-NR1D1 (phospho S59) Recombinant Antibody (BA0176)
SKU: CBMAB-0544CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

BA0176

Application

Immunogen

Human NR1D1 aa 50-150 (phospho S59)

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Introduction

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. There are two types, Rev-Erbalpha and Rev-Erbbeta. They are important in the regulation of circadian rhythm, as well as lipid homeostasis and lipid metabolism

Entrez Gene ID

9572

UniProt ID

P20393

Alternative Names

EAR1; hRev; THRA1; THRAL; ear-1

Ka, N. L., Park, M. K., Kim, S. S., Jeon, Y., Hwang, S., Kim, S. M., ... & Lee, M. O. (2023). NR1D1 stimulates antitumor immune responses in breast cancer by activating cGAS-STING signaling. Cancer Research, 83(18), 3045-3058.

Zhang-Sun, Z. Y., Xu, X. Z., Escames, G., Lei, W. R., Zhao, L., Zhou, Y. Z., ... & Yang, Y. (2023). Targeting NR1D1 in organ injury: challenges and prospects. Military Medical Research, 10(1), 62.

Yang, Y., Bai, Y., Wang, X., Guo, Y., Yu, Z., Feng, D., ... & Han, P. (2023, July). Clock gene NR1D1 might be a novel target for the treatment of bladder cancer. In Urologic Oncology: Seminars and Original Investigations (Vol. 41, No. 7, pp. 327-e9). Elsevier.

Noh, S. G., Jung, H. J., Kim, S., Arulkumar, R., Kim, D. H., Park, D., & Chung, H. Y. (2022). Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging. International Journal of Molecular Sciences, 23(17), 10032.

Wu, Z., Liao, F., Luo, G., Qian, Y., He, X., Xu, W., ... & Pu, J. (2021). NR1D1 deletion induces rupture-prone vulnerable plaques by regulating macrophage pyroptosis via the NF-κB/NLRP3 inflammasome pathway. Oxidative medicine and cellular longevity, 2021.

Hunter, A. L., Pelekanou, C. E., Barron, N. J., Northeast, R. C., Grudzien, M., Adamson, A. D., ... & Bechtold, D. A. (2021). Adipocyte NR1D1 dictates adipose tissue expansion during obesity. Elife, 10, e63324.

Wang, H., & Fu, Y. (2021). NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway. BMC cancer, 21(1), 1-12.

Liu, H., Zhu, Y., Gao, Y., Qi, D., Zhao, L., Zhao, L., ... & Xiao, J. (2020). NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis. Cell death & disease, 11(2), 129.

Murayama, Y., Yahagi, N., Takeuchi, Y., Aita, Y., Mehrazad Saber, Z., Wada, N., ... & Shimano, H. (2019). Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex. FEBS letters, 593(4), 423-432.

Ferder, I. C., Fung, L., Ohguchi, Y., Zhang, X., Lassen, K. G., Capen, D., ... & Wang, N. (2019). Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice. PLoS genetics, 15(5), e1008084.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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