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Mouse Anti-NR6A1 Recombinant Antibody (CBWJN-0151) (CBMAB-N3511-WJ)

This product is a Mouse antibody that recognizes NR6A1. The antibody CBWJN-0151 can be used for immunoassay techniques such as: ELISA, FC, ICC, IHC, WB.
See all NR6A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0151
Antibody Isotype
IgG1
Application
ELISA, FC, ICC, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.5% protein stabilizer
Preservative
0.05% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear receptor subfamily 6 group A member 1
Introduction
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]
Entrez Gene ID
2649
UniProt ID
Q15406
Alternative Names
Nuclear Receptor Subfamily 6 Group A Member 1; Retinoid Receptor-Related Testis-Specific Receptor; HGCNF; GCNF; HRTR; RTR; Retinoic Acid Receptor-Related Testis-Associated Receptor;
Function
Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
Biological Process
Gamete generationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Li, J., Mascarinas, P., & McGlinn, E. (2024). The expanding roles of Nr6a1 in development and evolution. Frontiers in Cell and Developmental Biology, 12, 1357968.

Wu, Q., Li, X., Long, M., Xie, X., & Liu, Q. (2023). Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. Scientific Reports, 13(1), 18642.

Lin, Z. H., Zhang, J., Zhuang, L. K., Xin, Y. N., & Xuan, S. Y. (2022). Establishment of a Prognostic Model for Hepatocellular Carcinoma Based on Bioinformatics and the Role of NR6A1 in the Progression of HCC. Journal of Clinical and Translational Hepatology, 10(5), 901.

Chang, Y. C., Manent, J., Schroeder, J., Wong, S. F. L., Hauswirth, G. M., Shylo, N. A., ... & McGlinn, E. (2022). Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development. Nature Communications, 13(1), 7766.

Tan, P., Xue, T., Wang, Y., Hu, Z., Su, J., Yang, R., ... & Lu, X. (2022). Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology, 209, 108990.

Liu, Z., Gao, Q., Wang, T., Chai, W., Zhan, Y., Akhtar, F., ... & Wang, C. (2022). Multi-Thoracolumbar variations and NR6A1 gene polymorphisms potentially associated with body size and carcass traits of Dezhou donkey. Animals, 12(11), 1349.

Liu, X., Fan, Z., Li, Y., Li, Z., Zhou, Z., Yu, X., ... & Li, D. (2020). microRNA‐196a‐5p inhibits testicular germ cell tumor progression via NR6A1/E‐cadherin axis. Cancer medicine, 9(23), 9107-9122.

Zhou, W., Jiang, R., Wang, Y., Li, Y., Sun, Z., & Zhao, H. (2020). hsa_circ_001653 up‐regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA‐377. Experimental Physiology, 105(12), 2141-2153.

Zhang, X., Li, C., Li, X., Liu, Z., Ni, W., Cao, Y., ... & Hu, S. (2019). Association analysis of polymorphism in the NR6A1 gene with the lumbar vertebrae number traits in sheep. Genes & genomics, 41, 1165-1171.

Fang, X., Lai, Z., Liu, J., Zhang, C., Li, S., Wu, F., ... & Dang, R. (2019). A Novel 13 bp Deletion within the NR6A1 Gene Is Significantly Associated with Growth Traits in Donkeys. Animals, 9(9), 681.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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