Mouse Anti-NRAP Recombinant Antibody (1E9) (CBMAB-N3514-WJ)

This product is a Mouse antibody that recognizes NRAP. The antibody 1E9 can be used for immunoassay techniques such as: ELISA, WB.
See all NRAP antibodies

Summary

Host Animal

Mouse

Specificity

Human

Clone

1E9

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Nebulin Related Anchoring Protein

Introduction

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

Entrez Gene ID

4892

UniProt ID

Q86VF7

Alternative Names

Nebulin Related Anchoring Protein; N-RAP; Nebulin-Related Anchoring Protein; Nebulin-Related-Anchoring Protein;

Function

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

Biological Process

Cardiac muscle thin filament assemblyManual Assertion Based On ExperimentIBA:GO_Central

References

Zhang, Z., Xu, K., Ji, L., Zhang, H., Yin, J., Zhou, M., ... & Yang, S. (2023). A novel loss-of-function mutation in NRAP is associated with left ventricular non-compaction cardiomyopathy. Frontiers in Cardiovascular Medicine, 10, 1097957.

Koskenvuo, J. W., Saarinen, I., Ahonen, S., Tommiska, J., Weckström, S., Seppälä, E. H., ... & Heliö, T. (2021). Biallelic loss-of-function in NRAP is a cause of recessive dilated cardiomyopathy. Plos one, 16(2), e0245681.

Ankit, S., Koranchery, R., Rajendran, R., Mohanan, K. S., Shenthar, J., & Dhandapany, P. S. (2019). Next generation sequencing reveals NRAP as a candidate gene for hypertrophic cardiomyopathy in elderly patients. bioRxiv, 789065.

Ahmed, H. A., Al-ghamdi, S., & Al Mutairi, F. (2019). Dilated cardiomyopathy in a child with truncating mutation in NRAP gene. Journal of Biochemical and Clinical Genetics, 1(2), 77-77.

Jirka, C., Pak, J. H., Grosgogeat, C. A., Marchetii, M. M., & Gupta, V. A. (2019). Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy. Human molecular genetics, 28(15), 2549-2560.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-NRAP Recombinant Antibody (H-5)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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