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Mouse Anti-NRIP1 Recombinant Antibody (6D7) (CBMAB-R0607-CN)

This product is a Mouse antibody that recognizes NRIP1. The antibody 6D7 can be used for immunoassay techniques such as: WB, IP, ChIP.
See all NRIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
6D7
Antibody Isotype
IgG1
Application
WB, IP, ChIP

Basic Information

Immunogen
Recombinant human RIP140 GST fusion protein
Specificity
Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.01% Thiomersal

Target

Full Name
Nuclear Receptor Interacting Protein 1
Introduction
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Mouse268903
Rat304157
UniProt ID
MouseQ8CBD1
RatG3V672
Alternative Names
Nuclear Receptor Interacting Protein 1; Nuclear Factor RIP140; Receptor-Interacting Protein 140; Nuclear Receptor-Interacting Protein 1; Receptor Interacting Protein 140; RIP140;
Function
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity).
Plays a role in renal development (PubMed:28381549).
Biological Process
Cellular response to estradiol stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Circadian regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Circadian rhythmManual Assertion Based On ExperimentIEP:UniProtKB
Lipid storageIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Ovarian follicle ruptureIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
Involvement in disease
Congenital anomalies of kidney and urinary tract 3 (CAKUT3):
A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. CAKUT3 inheritance is autosomal dominant.
PTM
Acetylation regulates its nuclear translocation and corepressive activity (By similarity).
Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.

Watanabe, F., Sato, S., Hirose, T., Endo, M., Endo, A., Ito, H., ... & Takahashi, K. (2024). NRIP1 regulates cell proliferation in lung adenocarcinoma cells. The Journal of Biochemistry, 175(3), 323-333.

Tsagkaraki, E., Guilherme, A., Nicoloro, S. M., Kelly, M., Lifshitz, L. M., Wang, H., ... & Czech, M. P. (2023). Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming. Molecular Metabolism, 76, 101780.

Ji, X., Lv, C., Huang, J., Dong, W., Sun, W., & Zhang, H. (2023). ALKBH5‐induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2. Cancer Science, 114(6), 2318.

Kerbs, P., Vosberg, S., Krebs, S., Graf, A., Blum, H., Swoboda, A., ... & Greif, P. A. (2022). Fusion gene detection by RNA-sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements. Haematologica, 107(1), 100.

Illangeswaran, R. S. S., Karathedath, S., Bagchi, A., Rajamani, B. M., Balakrishnan, B., Mathews, V., ... & Balasubramanian, P. (2021). Genetic Ablation of Nuclear Receptor Interacting Protein 1 (NRIP1) Sensitizes Acute Myeloid Leukemia Cells to Retinoic Acids. Blood, 138, 1146.

Zhou, J., Zhang, S., Sun, X., Lou, Y., & Yu, J. (2021). Hyperoside protects HK-2 cells against high glucose-induced apoptosis and inflammation via the miR-499a-5p/NRIP1 pathway. Pathology & Oncology Research, 27, 629829.

Li, C., Zhu, L., Fu, L., Han, M., Li, Y., Meng, Z., & Qiu, X. (2021). CircRNA NRIP1 promotes papillary thyroid carcinoma progression by sponging mir-195-5p and modulating the P38 MAPK and JAK/STAT pathways. Diagnostic pathology, 16, 1-11.

Binato, R., Corrêa, S., Panis, C., Ferreira, G., Petrone, I., da Costa, I. R., & Abdelhay, E. (2021). NRIP1 is activated by C-JUN/C-FOS and activates the expression of PGR, ESR1 and CCND1 in luminal A breast cancer. Scientific Reports, 11(1), 21159.

Chen, X., Jiang, J., Zhao, Y., Wang, X., Zhang, C., Zhuan, L., ... & Zheng, Y. (2020). Circular RNA circNTRK2 facilitates the progression of esophageal squamous cell carcinoma through up-regulating NRIP1 expression via miR-140-3p. Journal of Experimental & Clinical Cancer Research, 39, 1-14.

Liu, Y., Jiang, Y., Xu, L., Qu, C., Zhang, L., Xiao, X., ... & Wu, H. (2020). circ-NRIP1 promotes glycolysis and tumor progression by regulating miR-186-5p/MYH9 axis in gastric cancer. Cancer Management and Research, 5945-5956.

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For research use only. Not intended for any clinical use.

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