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Mouse Anti-NRK Recombinant Antibody (4C7) (CBMAB-N3598-WJ)

This product is a Mouse antibody that recognizes NRK. The antibody 4C7 can be used for immunoassay techniques such as: ELISA.
See all NRK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C7
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nik related kinase
Introduction
The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
Entrez Gene ID
203447
UniProt ID
Q7Z2Y5
Alternative Names
Nik Related Kinase; EC 2.7.11.1; Nik-Related Protein Kinase; EC 2.7.11; NESK;
Function
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm

Yomogita, H., Ito, H., Hashimoto, K., Kudo, A., Fukushima, T., Endo, T., ... & Kanai-Azuma, M. (2023). A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas. Journal of Reproduction and Development, 69(1), 32-40.

Lestari, B., Soda, K., Moritsugu, K., Kidera, A., Suenaga, Y., Hippo, Y., ... & Fukushima, T. (2023). The placental protein NRK promotes cell death through its plasma membrane-localizing CNH domain. bioRxiv, 2023-12.

Lestari, B., Naito, S., Endo, A., Nishihara, H., Kato, A., Watanabe, E., ... & Fukushima, T. (2022). Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2–PTEN–AKT Pathway and Placental Cell Proliferation. Molecular Biology and Evolution, 39(2), msab371.

Liu, G., Zhang, C., Wang, Y., Dai, G., Liu, S. Q., Wang, W., ... & Li, H. (2021). New exon and accelerated evolution of placental gene Nrk occurred in the ancestral lineage of placental mammals. Placenta, 114, 14-21.

Wei, T., Song, J., Liang, K., Li, L., Mo, X., Huang, Z., ... & Yang, J. (2021). Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment. Journal of Cancer Research and Clinical Oncology, 147, 1049-1064.

Naito, S., Fukushima, T., Endo, A., Denda, K., & Komada, M. (2020). Nik‐related kinase is targeted for proteasomal degradation by the chaperone‐dependent ubiquitin ligase CHIP. FEBS letters, 594(11), 1778-1786.

Lu, Y. J., Jan, Y. J., Ko, B. S., Liang, S. M., Chen, L., Wu, C. C., ... & Liou, J. Y. (2020). Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia. Aging (Albany NY), 12(8), 7511.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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