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Mouse Anti-NRL Recombinant Antibody (A-6) (CBMAB-N3600-WJ)

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Basic Information

Host Animal
Mouse
Clone
A-6
Application
WB, IP, IF, ELISA
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Neural Retina Leucine Zipper
Introduction
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4901
Mouse18185
Rat290221
UniProt ID
HumanP54845
MouseP54846
RatD4ACF4
Alternative Names
Neural Retina Leucine Zipper; D14S46E; Neural Retina-Specific Leucine Zipper Protein; Neural Retinal-Specific Leucine Zipper; NRL-MAF; RP27;
Function
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118).
Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001).
Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).
Biological Process
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to stimulusIEA:UniProtKB-KW
Retinal rod cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Retinitis pigmentosa 27 (RP27):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Retinal degeneration autosomal recessive clumped pigment type (RDCP):
A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present.
PTM
Phosphorylated (PubMed:11477108, PubMed:17335001).
Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation (By similarity).

Neil, G. J., Kluttig, K. H., & Allison, W. T. (2024). Determining Photoreceptor Cell Identity: Rod Versus Cone Fate Governed by tbx2b Opposing nrl. Investigative Ophthalmology & Visual Science, 65(1), 39-39.

Liang, X., Yadav, S. P., Batz, Z. A., Nellissery, J., & Swaroop, A. (2023). Protein kinase CK2 modulates the activity of Maf-family bZIP transcription factor NRL in rod photoreceptors of mammalian retina. Human Molecular Genetics, 32(6), 948-958.

Liang, X., Brooks, M. J., & Swaroop, A. (2022). Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human Molecular Genetics, 31(22), 3914-3933.

Liu, F., Qin, Y., Huang, Y., Gao, P., Li, J., Yu, S., ... & Liu, M. (2022). Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genetics, 18(3), e1009841.

El-Asrag, M. E., Corton, M., McKibbin, M., Avila-Fernandez, A., Mohamed, M. D., Blanco-Kelly, F., ... & Ali, M. (2022). Novel homozygous mutations in the transcription factor NRL cause non-syndromic retinitis pigmentosa. Molecular Vision, 28, 48.

Moore, S. M., Skowronska-Krawczyk, D., & Chao, D. L. (2020). Targeting of the NRL pathway as a therapeutic strategy to treat retinitis pigmentosa. Journal of Clinical Medicine, 9(7), 2224.

Oel, A. P., Neil, G. J., Dong, E. M., Balay, S. D., Collett, K., & Allison, W. T. (2020). Nrl is dispensable for specification of rod photoreceptors in adult zebrafish despite its deeply conserved requirement earlier in ontogeny. IScience, 23(12).

Kallman, A., Capowski, E. E., Wang, J., Kaushik, A. M., Jansen, A. D., Edwards, K. L., ... & Zack, D. J. (2020). Investigating cone photoreceptor development using patient-derived NRL null retinal organoids. Communications biology, 3(1), 82.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-NRL Recombinant Antibody (G-6) (CAT#: CBMAB-N3602-WJ)

Mouse Anti-NRL Recombinant Antibody (F-2) (CAT#: CBMAB-N3601-WJ)

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For research use only. Not intended for any clinical use.

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