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Mouse Anti-NSD1 Recombinant Antibody (CBT950) (V2LY-0625-LY3155)


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Tested Data
Mouse Anti-NSD1 Recombinant Antibody (CBT950) (V2LY-0625-LY3155) in WB
Mouse Anti-NSD1 Recombinant Antibody (CBT950) (V2LY-0625-LY3155) in WB

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT950
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Purified recombinant human NSD1 protein fragments expressed in E.coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Tris-Glycine, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
nuclear receptor binding SET domain protein 1
Entrez Gene ID
64324
UniProt ID
Q96L73
Function
Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone methylationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of histone H3-K36 methylationManual Assertion Based On ExperimentIMP:MGI
Regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIMP:MGI
Regulation of RNA polymerase II regulatory region sequence-specific DNA bindingManual Assertion Based On ExperimentIMP:MGI
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Involvement in disease
Sotos syndrome 1 (SOTOS1):
A childhood overgrowth syndrome characterized by pre- and postnatal overgrowth, developmental delay, mental retardation, advanced bone age, and abnormal craniofacial morphology including macrodolichocephaly with frontal bossing, frontoparietal sparseness of hair, apparent hypertelorism, downslanting palpebral fissures, and facial flushing. Common oral findings include: premature eruption of teeth; high, arched palate; pointed chin and, more rarely, prognathism.
Beckwith-Wiedemann syndrome (BWS):
A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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