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Mouse Anti-NUAK2 Recombinant Antibody (378CT15.4.5) (CBMAB-N3822-WJ)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
378CT15.4.5
Application
ELISA, WB
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
NUAK family, SNF1-like kinase, 2
Introduction
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate Ser-464 of LATS1.
Entrez Gene ID
81788
UniProt ID
Q9H093
Alternative Names
NUAK Family Kinase 2; SNF1/AMP Activated Protein Kinase; NUAK Family, SNF1-Like Kinase, 2; SNF1/AMP Kinase-Related Kinase; Omphalocele Kinase 2; EC 2.7.11.1;
Function
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Apoptotic processIEA:UniProtKB-KW
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Anencephaly 2 (ANPH2):
A form of anencephaly, an extreme neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH2 features may also include frontonasal dysplasia with midline cleft of the upper lip and alveolar ridge, bifid nose, and clinical anophthalmia. ANPH2 inheritance is autosomal recessive.
PTM
Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552).
Autophosphorylation is also possible at Thr-208 (PubMed:32845958).

Guo, Z., & Guo, L. (2024). OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession. Digestive and Liver Disease, 56(2), 352-362.

Singh, T., Beatty, A., & Peterson, J. R. (2022). The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells. Cell Death Discovery, 8(1), 253.

Lin, R., Wu, W., Chen, H., Gao, H., Wu, X., Li, G., ... & Liu, Z. (2022). GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2. Clinical and Translational Medicine, 12(3), e771.

Wang, D., Song, X., Zhang, N., & Guo, Y. (2022). MiR-1179 represses cell proliferation, migration and invasion of hepatocellular carcinoma through suppression of NUAK2. American Journal of Translational Research, 14(1), 223.

van de Vis, R. A., Moustakas, A., & van der Heide, L. P. (2021). NUAK1 And NUAK2 fine-tune TGF-β signaling. Cancers, 13(13), 3377.

Mammarella, E., Zampieri, C., Panatta, E., Melino, G., & Amelio, I. (2021). NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network. Biology Direct, 16(1), 11.

Li, Y., Song, X., Liu, L., & Yue, L. (2021). NUAK2 silencing inhibits the proliferation, migration and epithelial‑to‑mesenchymal transition of cervical cancer cells via upregulating CYFIP2. Molecular medicine reports, 24(5), 1-9.

Bonnard, C., Navaratnam, N., Ghosh, K., Chan, P. W., Tan, T. T., Pomp, O., ... & Reversade, B. (2020). A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling. Journal of Experimental Medicine, 217(12), e20191561.

Al-Busani, H., Al-Sobaihi, S., Nojima, K., Tanemura, A., Yaguchi, T., Kawakami, Y., ... & Namiki, T. (2020). NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP. Journal of dermatological science, 97(2), 143-151.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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