Rabbit Anti-NUB1 Recombinant Antibody (CBWJN-1591) (CBMAB-N3828-WJ)

Name: Rabbit Anti-NUB1 Recombinant Antibody (CBWJN-1591)
SKU: CBMAB-N3828-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBWJN-1591

Application

WB, FC

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

negative regulator of ubiquitin-like proteins 1

Introduction

This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Entrez Gene ID

Human	51667
Mouse	53312
Rat	296731

UniProt ID

Human	Q9Y5A7
Mouse	P54729
Rat	F7ES73

Alternative Names

Negative Regulator Of Ubiquitin Like Proteins 1; Renal Carcinoma Antigen NY-REN-18; NEDD8 Ultimate Buster-1; NYREN18; Negative Regulator Of Ubiquitin-Like Proteins 1; NEDD8 Ultimate Buster 1; NUB1L; BS4;

Function

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.

Biological Process

Positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to interferon-gammaManual Assertion Based On ExperimentIEP:UniProtKB
Response to tumor necrosis factorManual Assertion Based On ExperimentIEP:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Predominantly nuclear.

Jiang, W., Zhao, W., Ye, F., Huang, S., Wu, Y., Chen, H., ... & Fu, G. (2022). SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1. Atherosclerosis, 340, 1-11.

Arshad, M., Abdul Hamid, N., Chan, M. C., Ismail, F., Tan, G. C., Pezzella, F., & Tan, K. L. (2021). NUB1 and FAT10 proteins as potential novel biomarkers in cancer: A translational perspective. Cells, 10(9), 2176.

Zhang, D., Wu, P., Zhang, Z., An, W., Zhang, C., Pan, S., ... & Xu, H. (2020). Overexpression of negative regulator of ubiquitin-like proteins 1 (NUB1) inhibits proliferation and invasion of gastric cancer cells through upregulation of p27Kip1 and inhibition of epithelial-mesenchymal transition. Pathology-Research and Practice, 216(8), 153002.

Guarascio, R., Salih, D., Yasvoina, M., Edwards, F. A., Cheetham, M. E., & van der Spuy, J. (2020). Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy–lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment. Human molecular genetics, 29(1), 80-96.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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