Rabbit Anti-NUDT16L1 Recombinant Antibody (CBXS-1644) (CBMAB-S4493-CQ)

Name: Rabbit Anti-NUDT16L1 Recombinant Antibody (CBXS-1644)
SKU: CBMAB-S4493-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXS-1644

Application

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nudix Hydrolase 16 Like 1

Introduction

Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at Lys-20 (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).

Entrez Gene ID

Human	84309
Mouse	66911
Rat	497867

UniProt ID

Human	Q9BRJ7
Mouse	Q8VHN8
Rat	B0BNG7

Alternative Names

Nudix Hydrolase 16 Like 1; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16-Like 1; NUDT16-Like Protein 1; Protein Syndesmos; Syndesmos; SDOS; TIRR; Tudor-Interacting Repair Regulator Protein;

Function

Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136).
In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136).
Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136).
Binds U8 snoRNA (PubMed:18820299).

Biological Process

Negative regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

Lin, Y. S., Tsai, Y. C., Li, C. J., Wei, T. T., Wu, Y. N., Wu, S. R., ... & Lin, S. C. (2023). NUDT16L1 promotes colon cancer progression via inhibition of ferroptosis. Cancer Research, 83(7_Supplement), 1372-1372.

Anuchina, A. A., Smirnikhina, S. A., Zaynitdinova, M. I., Demchenko, A. G., Mishina, O. S., & Lavrov, A. V. (2021). NUDT16L1 (TIRR) knockdown increases genome editing efficacy. Medical Genetics, 20(8), 3-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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