Mouse Anti-NUFIP1 Recombinant Antibody (CBWJN-0327) (CBMAB-N3936-WJ)

This product is a Mouse antibody that recognizes NUFIP1. The antibody CBWJN-0327 can be used for immunoassay techniques such as: Dot, WB.
See all NUFIP1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBWJN-0327

Antibody Isotype

IgG1

Application

Dot, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

NUFIP1, FMR1 Interacting Protein 1

Introduction

This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012]

Entrez Gene ID

26747

UniProt ID

Q9UHK0

Alternative Names

NUFIP1, FMR1 Interacting Protein 1; Nuclear Fragile X Mental Retardation Protein Interacting Protein 1; Nuclear FMRP-Interacting Protein 1; Nuclear Fragile X Mental Retardation-Interacting Protein 1; BA540M5.1; NUFIP;

Function

Binds RNA.

Biological Process

Box C/D snoRNP assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:HGNC-UCL
RNA processingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Distributed in the nucleus in a dot-like pattern.

References

Sandborg, H., & Sherman, M. H. (2022). NUFIP1+ stroma keeps PDAC fed. Nature Cancer, 3(8), 909-910.

Yuan, M., Tu, B., Li, H., Pang, H., Zhang, N., Fan, M., ... & Zhao, Y. (2022). Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nature cancer, 3(8), 945-960.

Chagot, M. E., Boutilliat, A., Kriznik, A., & Quinternet, M. (2022). Structural analysis of the plasmodial proteins ZNHIT3 and NUFIP1 provides insights into the selectivity of a conserved interaction. Biochemistry, 61(7), 479-493.

Shen, A., Wu, M., Liu, L., Chen, Y., Chen, X., Zhuang, M., ... & Chen, F. (2021). Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells. Frontiers in Oncology, 11, 681425.

Shim, M. S., Nettesheim, A., Hirt, J., & Liton, P. B. (2020). The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. Autophagy, 16(7), 1248-1261.

Kim, H. G., Huot, J., Pin, F., Bonetto, A., & Nader, G. A. (2020). Muscle Wasting in Cancer Involves Suppression of Ribosomal Production and Increased Expression of the Ribophagy Receptor NUFIP1. The FASEB Journal, 34(S1), 1-1.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-NUFIP1 Recombinant Antibody (CBWJN-1611)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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