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Rabbit Anti-NUP107 Recombinant Antibody (CBWJN-1616) (CBMAB-N3982-WJ)

This product is a Rabbit antibody that recognizes NUP107. The antibody CBWJN-1616 can be used for immunoassay techniques such as: WB, IHC-P, ICC.
See all NUP107 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJN-1616
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.184 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nucleoporin 107
Introduction
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human57122
Mouse103468
Rat116555
UniProt ID
HumanP57740
MouseQ8BH74
RatP52590
Alternative Names
Nucleoporin 107; Nucleoporin 107kDa; Nuclear Pore Complex Protein Nup107; 107 KDa Nucleoporin; Nucleoporin Nup107; NPHS11; NUP84;
Function
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222).
Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102).
May anchor NUP62 to the NPC (PubMed:15229283).
Involved in nephrogenesis (PubMed:30179222).
Biological Process
Female gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
mRNA export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Nephron developmentManual Assertion Based On ExperimentIMP:UniProtKB
Nuclear pore complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Posttranscriptional tethering of RNA polymerase II gene DNA at nuclear peripheryManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus membrane
Nucleus, nuclear pore complex
Chromosome, centromere, kinetochore
Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755).
During mitosis, localizes to the kinetochores (PubMed:11564755).
Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755).
Involvement in disease
Nephrotic syndrome 11 (NPHS11):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS11 is an autosomal recessive, steroid-resistant and progressive form with onset in the first decade of life.
Ovarian dysgenesis 6 (ODG6):
A form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. ODG6 is an autosomal recessive condition.
Galloway-Mowat syndrome 7 (GAMOS7):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood. GAMOS7 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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