Rabbit Anti-NUP160 Recombinant Antibody (CBWJN-1622) (CBMAB-N3998-WJ)

Name: Rabbit Anti-NUP160 Recombinant Antibody (CBWJN-1622)
SKU: CBMAB-N3998-WJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Mouse, Rat, Human

Clone

CBWJN-1622

Antibody Isotype

IgG

Application

WB, FC

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

nucleoporin 160

Introduction

NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]

Entrez Gene ID

Human	23279
Mouse	59015
Rat	311182

UniProt ID

Human	Q12769
Mouse	Q9Z0W3
Rat	D3ZBL6

Alternative Names

Nucleoporin 160; 160 KDa Nucleoporin; Nucleoporin 160kDa; Nucleoporin Nup160; KIAA0197; NUP120;

Function

Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705).
Involved in poly(A)+ RNA transport.

Biological Process

mRNA export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nephron developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process protein transportIEA:UniProtKB-KW

Cellular Location

Nucleus, nuclear pore complex

Involvement in disease

Nephrotic syndrome 19 (NPHS19):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form that progresses to end-stage renal failure. NPHS19 is an autosomal recessive, steroid-resistant form with onset in the first or second decade of life, resulting in chronic kidney disease.

More Infomation

References

Li, Y., Yao, L., & Yu, Z. (2024). Mutations in NUP160 cause steroid-resistant nephrotic syndrome. Pediatric Nephrology, 1-3.

Nie, Y., Li, Y., Liu, M., Ma, B., Sui, X., Chen, J., ... & Dong, C. H. (2023). The nucleoporin NUP160 and NUP96 regulate nucleocytoplasmic export of mRNAs and participate in ethylene signaling and response in Arabidopsis. Plant Cell Reports, 42(3), 549-559.

Yu, Z., Li, Y., Xu, C., Zhao, F., Liu, Q., Qiu, X., ... & Qu, L. (2023). WCN23-0193 Podocyte-Specific Nup160 Knockout Mice Develop Nephrotic Syndrome and Glomerulosclerosis. Kidney International Reports, 8(3), S256-S257.

Xie, J., Chen, Z., Yao, G., Yuan, Y., Yu, W., & Zhu, Q. (2022). NUP160 knockdown inhibits the progression of diabetic nephropathy in vitro and in vivo. Regenerative Therapy, 21, 87-95.

Zhang, X. T., Dong, S. H., Zhang, J. Y., & Shan, B. (2019). MicroRNA-577 promotes the sensitivity of chronic myeloid leukemia cells to imatinib by targeting NUP160. European Review for Medical & Pharmacological Sciences, 23(16).

Zhao, F., Zhu, J. Y., Richman, A., Fu, Y., Huang, W., Chen, N., ... & Han, Z. (2019). Mutations in NUP160 are implicated in steroid-resistant nephrotic syndrome. Journal of the American Society of Nephrology, 30(5), 840-853.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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