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Rabbit Anti-NUP88 Recombinant Antibody (D7U4O) (CBMAB-N4025-WJ)

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Basic Information

Host Animal
Rabbit
Clone
D7U4O
Application
WB
Specificity
Human, Mouse, Rat, Hamster, Cattle, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Nucleoporin 88
Introduction
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Entrez Gene ID
Human4927
Mouse19069
Rat113929
Hamster101837580
Dog607268
Cattle504786
UniProt ID
HumanQ99567
MouseQ8CEC0
RatO08658
HamsterA0A3Q0CKX0
DogE2QXG1
CattleQ3SZ56
Alternative Names
Nucleoporin 88; Nucleoporin 88kDa; Nucleoporin Nup88; Nuclear Pore Complex Protein Nup88; Nuclear Pore Complex Protein 88; 88 KDa Nucleoporin; Nucleoporin 88kD; Karyoporin;
Function
Component of nuclear pore complex.
Biological Process
Mitotic cell cycleIEA:Ensembl
mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Ribosomal large subunit export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Ribosomal small subunit export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nuclear pore complex
Involvement in disease
Fetal akinesia deformation sequence 4 (FADS4):
A clinically and genetically heterogeneous group of disorders with congenital malformations related to impaired fetal movement. Clinical features include fetal akinesia, intrauterine growth retardation, polyhydramnios, arthrogryposis, pulmonary hypoplasia, craniofacial abnormalities, and cryptorchidism. FADS4 inheritance is autosomal recessive.

Singh, U., Bindra, D., Samaiya, A., & Mishra, R. K. (2023). Overexpressed Nup88 stabilized through interaction with Nup62 promotes NF-κB dependent pathways in cancer. Frontiers in Oncology, 13, 1095046.

Makise, M., Uchimura, R., Higashi, K., Mashiki, Y., Shiraishi, R., Shutoku, Y., & Kuniyasu, A. (2021). Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells. Histochemistry and Cell Biology, 156, 409-421.

Kindermann, B., Valkova, C., Krämer, A., Perner, B., Engelmann, C., Behrendt, L., ... & Kaether, C. (2019). The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia–associated NUP214 fusion proteins regulate Notch signaling. Journal of Biological Chemistry, 294(31), 11741-11750.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-NUP88 Recombinant Antibody (CBWJN-0293) (CAT#: CBMAB-N4024-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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