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Mouse Anti-NUP93 Recombinant Antibody (CBWJN-1627) (CBMAB-N4027-WJ)

This product is a Mouse antibody that recognizes NUP93. The antibody CBWJN-1627 can be used for immunoassay techniques such as: WB.
See all NUP93 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1627
Application
WB

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear pore complex protein Nup93
Introduction
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Entrez Gene ID
9688
UniProt ID
Q8N1F7
Alternative Names
Nucleoporin 93; 93 KDa Nucleoporin; Nucleoporin 93kDa; Nucleoporin Nup93; Nuclear Pore Complex Protein Nup93; KIAA0095; NIC96;
Function
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540).
May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).
Biological Process
Nuclear envelope organizationManual Assertion Based On ExperimentIDA:UniProtKB
Nuclear pore complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Poly(A)+ mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus membrane
Nucleus, nuclear pore complex
Nucleus envelope
Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.
Involvement in disease
Nephrotic syndrome 12 (NPHS12):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS12 inheritance is autosomal recessive.

Pan, L., Song, X. W., Song, J. C., Shi, C. Y., Wang, Z. K., Huang, S. Q., ... & Ge, J. B. (2023). Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription. Acta Pharmacologica Sinica, 44(5), 969-983.

Sonawane, P. J., S Dewangan, P., Madheshiya, P. K., Chopra, K., Kumar, M., Niranjan, S., ... & Chauhan, R. (2020). Molecular and structural analysis of central transport channel in complex with Nup93 of nuclear pore complex. Protein Science, 29(12), 2510-2527.

Monwan, W., Kawasaki, T., Hasan, M. Z., Ori, D., & Kawai, T. (2020). Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Biochemical and Biophysical Research Communications, 521(4), 1077-1082.

Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., & Hetzer, M. W. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life science alliance, 3(1).

Ouyang, X., Hao, X., Liu, S., Hu, J., & Hu, L. (2019). Expression of Nup93 is associated with the proliferation, migration and invasion capacity of cervical cancer cells. Acta biochimica et biophysica Sinica, 51(12), 1276-1285.

Zanni, G., De Magistris, P., Nardella, M., Bellacchio, E., Barresi, S., Sferra, A., ... & Antonin, W. (2019). Biallelic variants in the nuclear pore complex protein NUP93 are associated with non-progressive congenital ataxia. The Cerebellum, 18, 422-432.

Hashimoto, T., Harita, Y., Takizawa, K., Urae, S., Ishizuka, K., Miura, K., ... & Hattori, M. (2019). In vivo expression of NUP93 and its alteration by NUP93 mutations causing focal segmental glomerulosclerosis. Kidney International Reports, 4(9), 1312-1322.

Gomez, G. N., Abrar, F., Dodhia, M. P., Gonzalez, F. G., & Nag, A. (2019). SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex. Biochemistry and Cell Biology, 97(6), 758-766.

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For research use only. Not intended for any clinical use.

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