Mouse Anti-NUP93 Recombinant Antibody (CBWJN-1627) (CBMAB-N4027-WJ)

Name: Mouse Anti-NUP93 Recombinant Antibody (CBWJN-1627)
SKU: CBMAB-N4027-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-1627

Application

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nuclear pore complex protein Nup93

Introduction

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Entrez Gene ID

9688

UniProt ID

Q8N1F7

Alternative Names

Nucleoporin 93; 93 KDa Nucleoporin; Nucleoporin 93kDa; Nucleoporin Nup93; Nuclear Pore Complex Protein Nup93; KIAA0095; NIC96;

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540).
May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).

Biological Process

Nuclear envelope organizationManual Assertion Based On ExperimentIDA:UniProtKB
Nuclear pore complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Poly(A)+ mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus membrane
Nucleus, nuclear pore complex
Nucleus envelope
Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.

Involvement in disease

Nephrotic syndrome 12 (NPHS12):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS12 inheritance is autosomal recessive.

Pan, L., Song, X. W., Song, J. C., Shi, C. Y., Wang, Z. K., Huang, S. Q., ... & Ge, J. B. (2023). Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription. Acta Pharmacologica Sinica, 44(5), 969-983.

Sonawane, P. J., S Dewangan, P., Madheshiya, P. K., Chopra, K., Kumar, M., Niranjan, S., ... & Chauhan, R. (2020). Molecular and structural analysis of central transport channel in complex with Nup93 of nuclear pore complex. Protein Science, 29(12), 2510-2527.

Monwan, W., Kawasaki, T., Hasan, M. Z., Ori, D., & Kawai, T. (2020). Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Biochemical and Biophysical Research Communications, 521(4), 1077-1082.

Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., & Hetzer, M. W. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life science alliance, 3(1).

Ouyang, X., Hao, X., Liu, S., Hu, J., & Hu, L. (2019). Expression of Nup93 is associated with the proliferation, migration and invasion capacity of cervical cancer cells. Acta biochimica et biophysica Sinica, 51(12), 1276-1285.

Zanni, G., De Magistris, P., Nardella, M., Bellacchio, E., Barresi, S., Sferra, A., ... & Antonin, W. (2019). Biallelic variants in the nuclear pore complex protein NUP93 are associated with non-progressive congenital ataxia. The Cerebellum, 18, 422-432.

Hashimoto, T., Harita, Y., Takizawa, K., Urae, S., Ishizuka, K., Miura, K., ... & Hattori, M. (2019). In vivo expression of NUP93 and its alteration by NUP93 mutations causing focal segmental glomerulosclerosis. Kidney International Reports, 4(9), 1312-1322.

Gomez, G. N., Abrar, F., Dodhia, M. P., Gonzalez, F. G., & Nag, A. (2019). SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex. Biochemistry and Cell Biology, 97(6), 758-766.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
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For research use only. Not intended for any clinical use.

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