Rat Anti-OLFML3 (AA 22-406) Recombinant Antibody (CBXO-0394) (CBMAB-O0364-CQ)

Name: Rat Anti-OLFML3 (AA 22-406) Recombinant Antibody (CBXO-0394)
SKU: CBMAB-O0364-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXO-0394

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant human OLFM-L3, Gln22-Val406, Accession # Q8BK62

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS with Trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 22-406

More Infomation

Target

Full Name

olfactomedin-like 3

Introduction

This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

99543

UniProt ID

Q8BK62

Alternative Names

Olfactomedin Like 3; HNOEL-Iso; Olfactomedin-Like Protein 3; Olfactomedin-Like 3; Olfactomedin, 44-Kd; HOLF44; OLF44

Function

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).
May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

Biological Process

Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Chen, H., Li, R., Bian, J., Li, X., Su, C., Wang, Y., ... & Zhang, H. (2024). OLFML3 suppresses trophoblast apoptosis via the PI3K/AKT pathway: A possible therapeutic target in preeclampsia. Placenta, 147, 1-11.

Qu, S., Huang, C., Zhu, T., Wang, K., Zhang, H., Wang, L., ... & Qi, S. (2023). OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration. View, 4(2), 20220052.

Stalin, J., Imhof, B. A., Coquoz, O., Jeitziner, R., Hammel, P., McKee, T. A., ... & Miljkovic-Licina, M. (2021). Targeting OLFML3 in colorectal cancer suppresses tumor growth and angiogenesis, and increases the efficacy of anti-PD1 based immunotherapy. Cancers, 13(18), 4625.

Mei, H., Zha, Z., Wang, W., Xie, Y., Huang, Y., Li, W., ... & Liu, J. (2021). Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist. Genome biology, 22, 1-24.

Oliver, J. A., Wright, H., Massidda, P. A., Burmeister, L. M., & Mellersh, C. S. (2020). A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed‐angle glaucoma in Border Collies from the United Kingdom. Veterinary ophthalmology, 23(1), 25-36.

Pugh, C. A., Farrell, L. L., Carlisle, A. J., Bush, S. J., Ewing, A., Trejo-Reveles, V., ... & Summers, K. M. (2019). Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed. G3: Genes, Genomes, Genetics, 9(3), 943-954.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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