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Mouse Anti-OLR1 (AA 71-273) Recombinant Antibody (CBXO-0557) (CBMAB-O0104-CQ)

This product is a mouse antibody that recognizes OLR1 (AA 71-273). The antibody CBXO-0557 can be used for immunoassay techniques such as: IF, FuncS.
See all OLR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXO-0557
Antibody Isotype
IgG1
Application
IF, FuncS

Basic Information

Immunogen
Fusion protein of extracellular domain (aa 71-273) of human OLR1/LOX-1
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 71-273

Target

Full Name
Oxidized Low Density Lipoprotein Receptor 1
Introduction
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human4973
Mouse108078
UniProt ID
HumanP78380
MouseQ9EQ09
Alternative Names
Oxidized Low Density Lipoprotein Receptor 1; C-Type Lectin Domain Family 8 Member A; Lectin-Type Oxidized LDL Receptor 1; CLEC8A; HLOX-1; LOX1; Oxidised Low Density Lipoprotein (Lectin-Like) Receptor 1; Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1; Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form; Oxidized Low-Density Lipoprotein Receptor 1
Function
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
(Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis.
Biological Process
Blood circulationManual Assertion Based On ExperimentTAS:ProtInc
Cell deathManual Assertion Based On ExperimentIBA:GO_Central
Immune system processIEA:UniProtKB-KW
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Lipoprotein metabolic processManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Cell membrane
Membrane raft
Secreted
A secreted form also exists. Localization to membrane rafts requires palmitoylation.
Involvement in disease
Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to others (PubMed:15000751 and PubMed:15060104) they do not.
Topology
Cytoplasmic: 1-36
Helical: 43-65
Extracellular: 66-319
PTM
The intrachain disulfide-bonds prevent N-glycosylation at some sites.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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