Mouse Anti-OLR1 Recombinant Antibody (CBYJL-199) (CBMAB-L0281-YJ)

Name: Mouse Anti-OLR1 Recombinant Antibody (CBYJL-199)
SKU: CBMAB-L0281-YJ
Rating: 5 (1 reviews)

See all OLR1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-199

Application

FC, IHC

Immunogen

LOX-1 ectodomain: Fc fusion protein.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Oxidized Low Density Lipoprotein Receptor 1

Introduction

OLR1 is a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. OLR1 binds, internalizes and degrades oxidized low-density lipoprotein. OLR1 may be involved in the regulation of Fas-induced apoptosis. OLR1 may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

4973

UniProt ID

P78380

Alternative Names

Oxidized Low Density Lipoprotein Receptor 1; C-Type Lectin Domain Family 8 Member A; Lectin-Type Oxidized LDL Receptor 1; CLEC8A; HLOX-1; LOX1; Oxidised Low Density Lipoprotein (Lectin-Like) Receptor 1; Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1; Oxidized Low-Density Lipoprotein Receptor 1; Soluble Form; Oxidized Low-Density Lipoprotein Receptor 1

Function

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
(Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis.

Biological Process

Blood circulationManual Assertion Based On ExperimentTAS:ProtInc
Cell deathManual Assertion Based On ExperimentIBA:GO_Central
Immune system processIEA:UniProtKB-KW
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Lipoprotein metabolic processManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Cell membrane
Membrane raft
Secreted
A secreted form also exists. Localization to membrane rafts requires palmitoylation.

Involvement in disease

Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to others (PubMed:15000751 and PubMed:15060104) they do not.

Topology

Cytoplasmic: 1-36
Helical: 43-65
Extracellular: 66-319

PTM

The intrachain disulfide-bonds prevent N-glycosylation at some sites.
N-glycosylated.

Truthe, S., Klassert, T. E., Schmelz, S., Jonigk, D., Blankenfeldt, W., & Slevogt, H. (2024). Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions. Journal of Innate Immunity, 16(1), 105.

Korkmaz, F. T., Shenoy, A. T., Symer, E. M., Baird, L. A., Odom, C. V., Arafa, E. I., ... & Quinton, L. J. (2022). Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. JCI insight, 7(23).

Li, C., Liu, F., Yang, X., Guo, B., Li, G., Yin, J., ... & Wang, L. (2022). Targeting lectin-like oxidized low-density lipoprotein receptor-1 triggers autophagic program in esophageal cancer. Cell Death & Differentiation, 29(4), 697-708.

Zhang, H. Y., Lu, X., Hao, Y. H., Tang, L., & He, Z. Y. (2022). Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage. Neural Regeneration Research, 17(8), 1795-1801.

Mohammed, H. S. E. D., Kamal, M. M., ElBadre, H. M., Hosni, A., Elfadl, A. A., Mostafa, M. A., & El-Mahdy, R. I. (2022). Lectin-Like OLR1 3′ UTR Rs1050286 gene polymorphism and plasma Oxidized-LDL in coronary artery disease and their relation to cardiovascular risk and outcomes. Reports of Biochemistry & Molecular Biology, 10(4), 537.

Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T., & Kida, H. (2021). Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model. Scientific reports, 11(1), 15675.

Pokhrel, S., Gudneppanavar, R., Teegala, L. R., Duah, E., Thodeti, C. K., & Paruchuri, S. (2021). Leukotriene D4 upregulates oxidized low-density lipoprotein receptor 1 and CD36 to enhance oxidized LDL uptake and phagocytosis in macrophages through cysteinyl leukotriene receptor 1. Frontiers in Physiology, 12, 756450.

Gui, L. S., Raza, S. H. A., & Jia, J. (2019). Analysis of the oxidized low density lipoprotein receptor 1 gene as a potential marker for carcass quality traits in Qinchuan cattle. Asian-Australasian journal of animal sciences, 32(1), 58.

Jiang, L., Jiang, S., Zhou, W., Huang, J., Lin, Y., Long, H., & Luo, Q. (2019). Oxidized low density lipoprotein receptor 1 promotes lung metastases of osteosarcomas through regulating the epithelial-mesenchymal transition. Journal of translational medicine, 17, 1-11.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-OLR1 Recombinant Antibody (CBYJL-199)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-OLR1 Recombinant Antibody (9L455) (CAT#: CBMAB-L0292-YJ)

Rabbit Anti-OLR1 Recombinant Antibody (CBXO-0188) (CAT#: CBMAB-O0413-CQ)

Mouse Anti-OLR1 Recombinant Antibody (23C11) (CAT#: CBMAB-L0283-YJ)

Mouse Anti-OLR1 Recombinant Antibody (CBYJL-198) (CAT#: CBMAB-L0280-YJ)

Human Anti-OLR1 Recombinant Antibody (CBYCL-620) (CAT#: CBMAB-L0521-YC)

Mouse Anti-OLR1 Recombinant Antibody (CBYJL-205) (CAT#: CBMAB-L0289-YJ)

Recombinant Mouse Anti-OLR1 Antibody (CBHb212) (CAT#: CBMAB-Hb672-LY)

Mouse Anti-OLR1 Recombinant Antibody (CBXO-0418) (CAT#: CBMAB-O0407-CQ)

Mouse Anti-OLR1 Recombinant Antibody (CBYJL-197) (CAT#: CBMAB-L0279-YJ)

Rat Anti-Olr1 Recombinant Antibody (214012) (CAT#: CBMAB-L2969-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry