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Mouse Anti-ORAI2 Recombinant Antibody (CBXO-0562) (CBMAB-O0518-CQ)

This product is a mouse antibody that recognizes ORAI2. The antibody CBXO-0562 can be used for immunoassay techniques such as: WB.
See all ORAI2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0562
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Full length human Recombinant protein of human ORAI2 (NP_116220) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ORAI Calcium Release-Activated Calcium Modulator 2
Introduction
ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Platelet homeostasis. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI3.
Entrez Gene ID
80228
UniProt ID
Q96SN7
Alternative Names
ORAI Calcium Release-Activated Calcium Modulator 2; Transmembrane Protein 142B; CAP-Binding Protein Complex Interacting Protein 2; TMEM142B; C7orf19; CBCIP2; CAP-Binding Protein Complex-Interacting Protein 2
Function
Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.
Biological Process
Store-operated calcium entryManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane

Liu, K., Xu, P., Lv, J., Ge, H., Yan, Z., Huang, S., ... & Zhang, D. (2023). Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification. Oncogene, 42(24), 1980-1993.

Nakajima, H., Fujita, S., Kakae, M., Nagayasu, K., Oh‐hora, M., Shirakawa, H., & Kaneko, S. (2022). Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α‐stimulated astrocytes. Glia, 70(9), 1666-1680.

Yan, J., Yu, W., Lu, C., Wang, G., Liu, C., Jiang, L., ... & Liang, Z. (2022). Orai2 deficiency attenutates experimental colitis by facilitating the colonization of Akkermansia muciniphila. Genomics, 114(5), 110479.

Wu, S., Chen, M., Huang, J., Zhang, F., Lv, Z., Jia, Y., ... & Lam, K. O. (2021). ORAI2 promotes gastric cancer tumorigenicity and metastasis through PI3K/Akt signaling and MAPK-dependent focal adhesion disassembly. Cancer research, 81(4), 986-1000.

Sanchez-Collado, J., Lopez, J. J., Cantonero, C., Jardin, I., Regodón, S., Redondo, P. C., ... & Rosado, J. A. (2021). Orai2 modulates store-operated Ca2+ entry and cell cycle progression in breast cancer cells. Cancers, 14(1), 114.

Zhang, X., Xin, P., Yoast, R. E., Emrich, S. M., Johnson, M. T., Pathak, T., ... & Trebak, M. (2020). Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels. Cell calcium, 91, 102281.

Singh, A. K., Roy, N. K., Bordoloi, D., Padmavathi, G., Banik, K., Khwairakpam, A. D., ... & Sukumar, P. (2020). Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling. Life Sciences, 261, 118372.

Grimes, D., Johnson, R., Pashos, M., Cummings, C., Kang, C., Sampedro, G. R., ... & Clemens, R. A. (2020). ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proceedings of the National Academy of Sciences, 117(39), 24403-24414.

Stegner, D., Hofmann, S., Schuhmann, M. K., Kraft, P., Herrmann, A. M., Popp, S., ... & Nieswandt, B. (2019). Loss of Orai2-mediated capacitative Ca2+ entry is neuroprotective in acute ischemic stroke. Stroke, 50(11), 3238-3245.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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