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Rat Anti-ORC3 Recombinant Antibody (1D6) (CBMAB-O0541-CQ)

This product is a rat antibody that recognizes ORC3. The antibody 1D6 can be used for immunoassay techniques such as: IP, WB.
See all ORC3 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
1D6
Antibody Isotype
IgG2b
Application
IP, WB

Basic Information

Immunogen
Full length human ORC3L protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Origin Recognition Complex Subunit 3
Introduction
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Entrez Gene ID
23595
UniProt ID
Q9UBD5
Alternative Names
Origin Recognition Complex Subunit 3; Origin Recognition Complex Subunit Latheo; LATHEO; ORC3L; Origin Recognition Complex, Subunit 3 (Yeast Homolog)-Like; Origin Recognition Complex, Subunit 3 Honolog (Yeast)
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Cellular Location
Nucleus
Chromosome
PTM
Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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