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Mouse Anti-OSR1 Recombinant Antibody (CBXO-0032) (CBMAB-O0315-CQ)

This product is a mouse antibody that recognizes OSR1. The antibody CBXO-0032 can be used for immunoassay techniques such as: IF, S-ELISA, ELISA, IHC-P.
See all OSR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0032
Antibody Isotype
IgG2b, Κ
Application
IF, S-ELISA, ELISA, IHC-P

Basic Information

Immunogen
OSR1 (NP_660303, 1 a.a.-100 a.a) partial Recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
odd-skipped related 1 (Drosophila)
Introduction
OSR1 (Odd-Skipped Related Transciption Factor 1) is a Protein Coding gene. Diseases associated with OSR1 include Hydronephrosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is OSR2.
Entrez Gene ID
130497
UniProt ID
Q8TAX0
Alternative Names
Odd-Skipped Related Transciption Factor 1; ODD; Odd-Skipped Related 1 (Drosophila); Odd-Skipped (Drosophila) Homolog; Protein Odd-Skipped-Related 1; Odd-Skipped Related 1; Odd-Skipped Homolog
Function
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
Biological Process
Cell differentiationISS:BHF-UCL
Cell proliferation involved in kidney developmentISS:UniProtKB
Cellular response to retinoic acidIEA:Ensembl
Chondrocyte differentiationISS:BHF-UCL
Embryonic digit morphogenesisISS:BHF-UCL
Embryonic forelimb morphogenesisISS:BHF-UCL
Embryonic hindlimb morphogenesisISS:BHF-UCL
Embryonic skeletal joint developmentISS:BHF-UCL
Embryonic skeletal joint morphogenesisISS:BHF-UCL
Embryonic skeletal limb joint morphogenesisISS:BHF-UCL
Gonad developmentIEA:Ensembl
Heart developmentISS:UniProtKB
Intermediate mesoderm developmentIEA:Ensembl
Mesangial cell developmentISS:UniProtKB
Mesonephric duct morphogenesisISS:UniProtKB
Mesonephros developmentISS:UniProtKB
Metanephric cap mesenchymal cell proliferation involved in metanephros developmentISS:UniProtKB
Metanephric epithelium developmentISS:UniProtKB
Metanephric glomerulus vasculature developmentISS:UniProtKB
Metanephric interstitial fibroblast developmentISS:UniProtKB
Metanephric mesenchymal cell differentiationISS:UniProtKB
Metanephric mesenchyme developmentISS:UniProtKB
Metanephric mesenchyme morphogenesisISS:UniProtKB
Metanephric nephron tubule developmentISS:UniProtKB
Metanephric smooth muscle tissue developmentISS:UniProtKB
Middle ear morphogenesisISS:UniProtKB
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of creatine transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of epithelial cell differentiationISS:UniProtKB
Negative regulation of nephron tubule epithelial cell differentiationISS:UniProtKB
Negative regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
OdontogenesisISS:UniProtKB
Pattern specification involved in metanephros developmentISS:UniProtKB
Positive regulation of bone mineralizationISS:BHF-UCL
Positive regulation of epithelial cell proliferationISS:UniProtKB
Positive regulation of gastrulationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Posterior mesonephric tubule developmentISS:UniProtKB
Pronephros developmentManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Renal vesicle progenitor cell differentiationISS:UniProtKB
Roof of mouth developmentISS:UniProtKB
Specification of anterior mesonephric tubule identityISS:UniProtKB
Specification of posterior mesonephric tubule identityISS:UniProtKB
Stem cell differentiationISS:UniProtKB
Ureter urothelium developmentISS:UniProtKB
Ureteric bud developmentISS:UniProtKB
Urogenital system developmentISS:UniProtKB
Cellular Location
Nucleus

Kotsaris, G., Qazi, T. H., Bucher, C. H., Zahid, H., Pöhle-Kronawitter, S., Ugorets, V., ... & Stricker, S. (2023). Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors. npj Regenerative Medicine, 8(1), 19.

Yu, Z., & Ouyang, L. (2023). OSR1 downregulation indicates an unfavorable prognosis and activates the NF-κB pathway in ovarian cancer. Discover Oncology, 14(1), 159.

Yu, Z., & Ouyang, L. (2022). Odd-skipped related 1 plays a tumor suppressor role in ovarian cancer via promoting follistatin-like protein 1 transcription. Human Cell, 35(6), 1824-1837.

Lynch, E. C., Liu, Z., Liu, L., Wang, X., Zhang, K. K., & Xie, L. (2022). Disrupting Osr1 expression promoted hepatic steatosis and inflammation induced by high-fat diet in the mouse model. Plos one, 17(6), e0268344.

Zhou, Y., Liu, Z., Lynch, E. C., He, L., Cheng, H., Liu, L., ... & Xie, L. (2021). Osr1 regulates hepatic inflammation and cell survival in the progression of non-alcoholic fatty liver disease. Laboratory Investigation, 101(4), 477-489.

Wang, Y., Lei, L., Xu, F., & Xu, H. T. (2020). Reduced expression of odd‑skipped related transcription factor 1 promotes proliferation and invasion of breast cancer cells and indicates poor patient prognosis. Oncology Letters, 20(3), 2946-2954.

Zhang, F., & Jiang, Z. (2020). Downregulation of OSR1 promotes colon adenocarcinoma progression via FAK-mediated Akt and MAPK signaling. OncoTargets and therapy, 3489-3500.

Chen, W., Wu, K., Zhang, H., Fu, X., Yao, F., & Yang, A. (2019). Corrigendum to" Odd-skipped related transcription factor 1 (OSR1) suppresses tongue squamous cell carcinoma migration and invasion through inhibiting NF-κB pathway"[Eur. J. Pharmacol. 15 (2018) 33-39]. European journal of pharmacology, 847, 158.

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For research use only. Not intended for any clinical use.

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