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Mouse Anti-OTOL1 (AA 24-477) Recombinant Antibody (CBXO-0399) (CBMAB-O0691-CQ)

This product is a mouse antibody that recognizes OTOL1 (AA 24-477). The antibody CBXO-0399 can be used for immunoassay techniques such as: WB, ICC.
See all OTOL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0399
Antibody Isotype
IgG1
Application
WB, ICC

Basic Information

Immunogen
CHO-derived recombinant human Otolin-1, Lys24-Pro477, Accession # A6NHN0
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 24-477

Target

Full Name
Otolin 1
Introduction
This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance deficits resulting from vestibular dysfunction.
Entrez Gene ID
131149
UniProt ID
A6NHN0
Alternative Names
Otolin 1; C1q And TNF Related 16; C1q And Tumor Necrosis Factor Related Protein 15; Otolin 1 Homolog (Zebrafish); C1QTNF15; C1QTNF16; Otolin-1
Function
Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics.
Biological Process
Collagen-activated tyrosine kinase receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Otolith mineralizationISS:UniProtKB
Protein homooligomerizationISS:UniProtKB
Cellular Location
Secreted, extracellular space, extracellular matrix
Localized in both the surrounding otoconial matrix and otoconia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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