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Mouse Anti-OTP (AA 11-120) Recombinant Antibody (CBXO-0287) (CBMAB-O0697-CQ)

This product is a mouse antibody that recognizes OTP (AA 11-120). The antibody CBXO-0287 can be used for immunoassay techniques such as: ELISA, WB.
See all OTP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0287
Antibody Isotype
IgG2a, Κ
Application
ELISA, WB

Basic Information

Immunogen
OTP (NP_115485.1, 11aa-120aa) partial Recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 11-120

Target

Full Name
orthopedia homeobox
Introduction
This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development.
Entrez Gene ID
23440
UniProt ID
Q5XKR4
Alternative Names
Orthopedia Homeobox; Orthopedia Homolog (Drosophila)
Function
Probably involved in the differentiation of hypothalamic neuroendocrine cells.
Biological Process
Forebrain neuron differentiationIEA:Ensembl
Hypothalamus cell differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Neurohypophysis developmentIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neuroblast proliferationIEA:Ensembl
Cellular Location
Nucleus

Vesterinen, T., & Arola, J. (2023). Orthopedia homeobox protein (OTP) in the diagnostic and prognostic workup of pulmonary carcinoid tumors. Translational lung cancer research, 12(1), 1.

Moonen, L., Mangiante, L., Leunissen, D. J., Lap, L. M., Gabriel, A., Hillen, L. M., ... & Speel, E. J. M. (2022). Differential Orthopedia Homeobox expression in pulmonary carcinoids is associated with changes in DNA methylation. International Journal of Cancer, 150(12), 1987-1997.

Moonen, L., Derks, J. L., Lap, L. M., Marijnissen, B. J., Hillen, L. M., den Bakker, M. A., ... & Speel, E. J. M. (2022). Development and verification of new monoclonal orthopedia homeobox (OTP) specific antibodies for pulmonary carcinoid diagnostics. Translational lung cancer research, 11(11), 2181.

Moonen, L., Mangiante, L., Alcala, N., Leunissen, D., Lap, L., Gabriel, A., ... & Speel, E. (2021). P66. 09 Differential Orthopedia Homeobox (OTP) Expression in Pulmonary Carcinoids is Regulated Through Methylation. Journal of Thoracic Oncology, 16(10), S1196-S1197.

Hildebrandt, K., Bach, N., Kolb, D., & Walldorf, U. (2020). The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut. Hereditas, 157, 1-13.

Viswanathan, K., Borczuk, A. C., & Siddiqui, M. T. (2019). Orthopedia homeobox protein (OTP) is a sensitive and specific marker for primary pulmonary carcinoid tumors in cytologic and surgical specimens. Journal of the American Society of Cytopathology, 8(1), 39-46.

Moonen, L., Derks, J., Dingemans, A. M., & Speel, E. J. (2019). Orthopedia homeobox (OTP) in pulmonary neuroendocrine tumors: the diagnostic value and possible molecular interactions. Cancers, 11(10), 1508.

Roy, M., Buehler, D. G., Zhang, R., Schwalbe, M. L., Baus, R. M., Salamat, M. S., ... & Rosenbaum, J. N. (2019). Expression of insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) in tumors with neuroendocrine differentiation at rare sites. Endocrine Pathology, 30, 35-42.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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