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Mouse Anti-OVOL1 (AA 1-267) Recombinant Antibody (1B3) (CBMAB-O0780-CQ)

This product is a mouse antibody that recognizes OVOL1 (AA 1-267). The antibody 1B3 can be used for immunoassay techniques such as: ELISA.
See all OVOL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B3
Antibody Isotype
IgG1, Κ
Application
ELISA

Basic Information

Immunogen
OVOL1 (AAH59408, 1 a.a.-267 a.a) full-length Recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-267

Target

Full Name
ovo-like 1(Drosophila)
Introduction
This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well.
Entrez Gene ID
5017
UniProt ID
O14753
Alternative Names
Ovo Like Transcriptional Repressor 1; Ovo-Like 1(Drosophila); Ovo Like Zinc Finger 1; HOVO1; Putative Transcription Factor Ovo-Like 1; Ovo (Drosophila) Homolog-Like 1; Ovo Homolog-Like 1
Function
Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).
Biological Process
Epidermal cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Germline cell cycle switching, mitotic to meiotic cell cycleIEA:Ensembl
Kidney developmentIEA:Ensembl
Mesoderm developmentIEA:Ensembl
Negative regulation of meiotic cell cycle phase transitionIEA:Ensembl
Negative regulation of stem cell proliferationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skin developmentIEA:Ensembl
SpermatogenesisIEA:Ensembl
Cellular Location
Nucleus

Dragan, M., Chen, Z., Li, Y., Le, J., Sun, P., Haensel, D., ... & Dai, X. (2023). Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism. EMBO reports, 24(7), e56214.

Dragan, M., Sun, P., Chen, Z., Ma, X., Vu, R., Shi, Y., ... & Dai, X. (2022). Epidermis-intrinsic transcription factor Ovol1 coordinately regulates barrier maintenance and neutrophil accumulation in psoriasis-like inflammation. Journal of Investigative Dermatology, 142(3), 583-593.

Saxena, K., Srikrishnan, S., Celia-Terrassa, T., & Jolly, M. K. (2022). OVOL1/2: drivers of epithelial differentiation in development, disease, and reprogramming. Cells Tissues Organs, 211(2), 183-192.

Fan, C., Wang, Q., van der Zon, G., Ren, J., Agaser, C., Slieker, R. C., ... & Ten Dijke, P. (2022). OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor. Signal Transduction and Targeted Therapy, 7(1), 126.

Sun, P., Vu, R., Dragan, M., Haensel, D., Gutierrez, G., Nguyen, Q., ... & Dai, X. (2021). OVOL1 regulates psoriasis-like skin inflammation and epidermal hyperplasia. Journal of Investigative Dermatology, 141(6), 1542-1552.

Sun, X., Li, Z., Niu, Y., Zhao, L., Huang, Y., Li, Q., ... & Zhang, J. (2019). Jarid1b promotes epidermal differentiation by mediating the repression of Ship1 and activation of the AKT/Ovol1 pathway. Cell Proliferation, 52(5), e12638.

Kagawa, H., Shimamoto, R., Kim, S. I., Oceguera-Yanez, F., Yamamoto, T., Schroeder, T., & Woltjen, K. (2019). OVOL1 influences the determination and expansion of iPSC reprogramming intermediates. Stem cell reports, 12(2), 319-332.

Xu, C., Yan, T., & Yang, J. (2019). OVOL1 inhibits oral squamous cell carcinoma growth and metastasis by suppressing zinc finger E-box binding homeobox 1. International Journal of Clinical and Experimental Pathology, 12(7), 2801.

Furue, K., Ito, T., Tsuji, G., Ulzii, D., Vu, Y. H., Kido‐Nakahara, M., ... & Furue, M. (2019). The IL‐13–OVOL 1–FLG axis in atopic dermatitis. Immunology, 158(4), 281-286.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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