Mouse Anti-OXSM (AA 78-343) Recombinant Antibody (4E10) (CBMAB-O0801-CQ)

This product is a mouse antibody that recognizes OXSM (AA 78-343). The antibody 4E10 can be used for immunoassay techniques such as: IHC-P, WB.
See all OXSM antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4E10

Antibody Isotype

IgG2b

Application

IHC-P, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 78-343

Target

Full Name

3-Oxoacyl-ACP Synthase, Mitochondrial

Introduction

This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.

Entrez Gene ID

54995

UniProt ID

Q9NWU1

Alternative Names

3-Oxoacyl-ACP Synthase, Mitochondrial; Beta-Ketoacyl-ACP Synthase; Beta-Ketoacyl Synthase; EC 2.3.1.41; 3-Oxoacyl-[Acyl-Carrier-Protein] Synthase, Mitochondrial; Acyl-Malonyl Acyl Carrier Protein-Condensing Enzyme; Type II Mitochondrial Beta-Ketoacyl Synthase; 3-Ketoacyl-Acyl Carrier Protein Synthase

Function

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.

Biological Process

Acyl-CoA metabolic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Fatty acid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Medium-chain fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Short-chain fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:HGNC-UCL

Cellular Location

Mitochondrion

References

Duan, Y., Yu, J., Chen, M., Lu, Q., Ning, F., Gan, X., ... & Lash, G. E. (2023). Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). Journal of Ovarian Research, 16(1), 81.

Wang, W. Y., & Lu, W. C. (2020). Reduced expression of hsa-miR-338-3p contributes to the development of glioma cells by targeting mitochondrial 3-Oxoacyl-ACP Synthase (OXSM) in glioblastoma (GBM). OncoTargets and therapy, 9513-9523.

Gao, T., Qian, S., Shen, S., Zhang, X., Liu, J., Jia, W., ... & Ye, J. (2019). Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice. Biochemical and biophysical research communications, 512(1), 106-111.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-OXSM Recombinant Antibody (1H6)

Mouse Anti-OXSM (AA 78-343) Recombinant Antibody (3A4)

Mouse Anti-OXSM Recombinant Antibody (1G5)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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