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Mouse Anti-P2RX2 Recombinant Antibody (3D5) (CBMAB-P0582-YC)

Provided herein is a Mouse monoclonal antibody against Human Purinergic Receptor P2X 2. The antibody can be used for immunoassay techniques, such as WB, IP, ELISA.
See all P2RX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D5
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
purinergic receptor P2X, ligand-gated ion channel, 2
Introduction
P2RX2 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Entrez Gene ID
22953
UniProt ID
Q9UBL9
Alternative Names
DFNA41; P2X2
Function
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K+ recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
Biological Process
Behavioral response to painIEA:Ensembl
Detection of hypoxic conditions in blood by carotid body chemoreceptor signalingIEA:Ensembl
Neuromuscular junction developmentIEA:Ensembl
Neuromuscular synaptic transmissionIEA:Ensembl
PeristalsisIEA:Ensembl
Positive regulation of calcium ion transport into cytosol1 PublicationNAS:BHF-UCL
Positive regulation of calcium-mediated signaling1 PublicationNAS:BHF-UCL
Response to ATPIEA:Ensembl
Response to carbohydrateIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to ischemiaISS:ARUK-UCL
Sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Sensory perception of tasteIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
Urinary bladder smooth muscle contractionIEA:Ensembl
Cellular Location
Cell membrane
Localizes to the apical membranes of hair cells in the organ of Corti.
Involvement in disease
Deafness, autosomal dominant, 41 (DFNA41):
A form of non-syndromic deafness characterized by onset of progressive sensorineural hearing loss usually in the second decade. The hearing loss is severe and ultimately affects all frequencies. Exposure to noise exacerbates the hearing loss, particularly at high frequencies.
Topology
Cytoplasmic: 1-42
Helical: 43-63
Extracellular: 64-337
Helical: 338-358
Cytoplasmic: 359-471

Zhao, W., Song, S., Chu, W., Li, Y., Chen, S., Ji, Y., ... & Ji, F. (2022). Disruption of hippocampal P2RX2/CaMKII/NF-κB signaling contributes to learning and memory impairment in C57BL/6 mice induced by surgery plus anesthesia in neonatal period. Biomedicine & Pharmacotherapy, 149, 112897.

Li, Q., Wu, B., Daba, M., Gao, X., Chen, B., Song, G., ... & Liu, B. (2022). Identification of Calcium Channel-Related Gene P2RX2 for Prognosis and Immune Infiltration in Prostate Cancer. Disease Markers, 2022.

Malamiri, R. A., Asl, J. M., & Ghanbari, F. (2021). Identification of a novel stop loss mutation in p2rx2 gene in an iranian family with autosomal nonsyndromic hearing loss. Iranian Biomedical Journal, 25(5), 368.

Chen, X., Abad, C., Chen, Z. Y., Young, J. I., Gurumurthy, C. B., Walz, K., & Liu, X. Z. (2021). Generation and characterization of a P2rx2 V60L mouse model for DFNA41. Human molecular genetics, 30(11), 985-995.

Liu, X. Z., Yan, D., Mittal, R., Ballard, M. E., & Feng, Y. (2020). Progressive Dominant Hearing Loss (Autosomal Dominant Deafness‐41) and P2RX2 Gene Mutations: A Phenotype–Genotype Study. The Laryngoscope, 130(7), 1657-1663.

Jeong, J., Kim, J. Y., Hong, H., Wangemann, P., Marcus, D. C., Jung, J., ... & Kim, S. H. (2020). P2RX2 and P2RX4 receptors mediate cation absorption in transitional cells and supporting cells of the utricular macula. Hearing Research, 386, 107860.

Gosstola, N. C., Huang, Z., Tong, X., Nourbakhsh, A., Chen, Z. Y., Dykxhoorn, D. M., & Liu, X. Z. (2020). Characterization of UMi028-A-1 stem cell line that contains a CRISPR/Cas9 induced hearing loss-associated variant (V60L (c. 178G> T)) in the P2RX2 gene. Stem cell research, 49, 102017.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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