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Mouse Anti-PABPC1L Recombinant Antibody (H-1) (CBMAB-P0627-YC)

Provided herein is a Mouse monoclonal antibody against Mouse Poly(A) Binding Protein Cytoplasmic 1 Like. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PABPC1L antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
H-1
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Poly(A) Binding Protein Cytoplasmic 1 Like
Introduction
PABPC1L has ubiquitous expression in thyroid (RPKM 9.7), lymph node (RPKM 6.0) and 25 other tissues.
Entrez Gene ID
381404
UniProt ID
A2A5N3
Alternative Names
Poly(A) Binding Protein Cytoplasmic 1 Like; C20orf119; Poly(A) Binding Protein, Cytoplasmic 1-Like; Chromosome 20 Open Reading Frame 119; Polyadenylate-Binding Protein 1-Like; Embryonic Poly(A) Binding Protein; DJ1069P2.3; PABPC1L1; EPAB;
Cellular Location
cytoplasmic stress granule
cytosol
extracellular exosome
nucleus
ribonucleoprotein complex

Meng, X., Xiao, W., Sun, J., Li, W., Yuan, H., Yu, T., ... & Dong, W. (2023). CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. Cancer Letters, 554, 216023.

Wang, W., Guo, J., Shi, J., Li, Q., Chen, B., Pan, Z., ... & Wang, L. (2023). Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility. EMBO Molecular Medicine, 15(6), e17177.

Wang, X., Zhou, R., Lu, X., Dai, S., Liu, M., Jiang, C., ... & Liu, H. (2023). Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility. Clinical Genetics, 104(6), 648-658.

Qi, Y., Wang, M., & Jiang, Q. (2022). PABPC1——mRNA stability, protein translation and tumorigenesis. Frontiers in Oncology, 12, 1025291.

Wegler, M., Jia, X., Alders, M., Bouman, A., Chen, J., Duan, X., ... & Abou Jamra, R. (2022). De novo variants in the PABP domain of PABPC1 lead to developmental delay. Genetics in Medicine, 24(8), 1761-1773.

Feng, C., Han, Y. H., Qi, N., Li, J., Sheng, Q. H., Liu, Y., & Yang, L. L. (2021). Functional implications of PABPC1 in the development of ovarian cancer. Open Medicine, 16(1), 805-815.

Smith, E. M., Benbahouche, N. E. H., Morris, K., Wilczynska, A., Gillen, S., Schmidt, T., ... & Bushell, M. (2021). The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction. Nucleic acids research, 49(1), 458-478.

YuFeng, Z., & Ming, Q. (2020). Expression and prognostic roles of PABPC1 in hepatocellular carcinoma. International Journal of Surgery, 84, 3-12.

Wang, Q., Wang, Z., Bao, Z., Zhang, C., Wang, Z., & Jiang, T. (2020). PABPC1 relevant bioinformatic profiling and prognostic value in gliomas. Future Oncology, 16(01), 4279-4288.

Wu, Y. Q., Ju, C. L., Wang, B. J., & Wang, R. G. (2019). PABPC1L depletion inhibits proliferation and migration via blockage of AKT pathway in human colorectal cancer cells. Oncology letters, 17(3), 3439-3445.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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