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Mouse Anti-PAFAH1B2 Recombinant Antibody (2F4-1C10) (CBMAB-P0656-YC)

Provided herein is a Mouse monoclonal antibody against Human Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all PAFAH1B2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F4-1C10
Antibody Isotype
IgM, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa1-230 from human PAFAH1B2 (AAH00398) with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 2
Introduction
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene.
Entrez Gene ID
5049
UniProt ID
P68402
Alternative Names
Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 2; Platelet-Activating Factor Acetylhydrolase 1b, Catalytic Subunit 2 (30kDa); Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Subunit 2 (30kDa); PAF Acetylhydrolase 30 KDa Subunit; PAF-AH1b Alpha 2 Subunit; PAF-AH 30 KDa Subunit; PAF-AH Subunit Beta; PAFAH Subunit Beta;
Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity).
May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity).
Biological Process
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Lipid catabolic processIEA:UniProtKB-KW
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of macroautophagyManual Assertion Based On ExperimentIMP:BHF-UCL
SpermatogenesisISS:UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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