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Mouse Anti-PAFAH2 Recombinant Antibody (1A8) (CBMAB-P0666-YC)

Provided herein is a Mouse monoclonal antibody against Human Platelet Activating Factor Acetylhydrolase 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all PAFAH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
platelet-activating factor acetylhydrolase 2, 40kDa
Introduction
PAFAH2 is platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.
Entrez Gene ID
5051
UniProt ID
Q99487
Alternative Names
Platelet Activating Factor Acetylhydrolase 2; Platelet-Activating Factor Acetylhydrolase 2, 40kDa; Serine-Dependent Phospholipase A2; EC 3.1.1.47; HSD-PLA2; SD-PLA2; Platelet-Activating Factor Acetylhydrolase 2, Cytoplasmic; Platelet-Activating Factor Acetylhydrolase 2 (40kD); EC 3.1.1;
Function
Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101).
Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity).
Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity).
Biological Process
Blood coagulationTAS:Reactome
Lipid catabolic processIEA:UniProtKB-KW
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Membrane
Endoplasmic reticulum membrane
In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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