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Mouse Anti-PAK5 Recombinant Antibody (CBYC-P148) (CBMAB-P0708-YC)

Provided herein is a Mouse monoclonal antibody against Human P21 (RAC1) Activated Kinase 5. The antibody can be used for immunoassay techniques, such as WB, IHC.
See all PAK5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYC-P148
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
E. coli-derived Recombinant human PAK7, Met1-Glu134
Specificity
Human, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
P21 (RAC1) Activated Kinase 5
Introduction
PAK5 (P21 (RAC1) Activated Kinase 5) is a protein coding gene. Among its related pathways are Focal Adhesion and T cell receptor signaling pathway. An important paralog of the gene is PAK4.
Entrez Gene ID
Human57144
Rat311450
UniProt ID
HumanQ9P286
RatD4A280
Alternative Names
PAK7
Function
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Cell migrationManual Assertion Based On ExperimentTAS:UniProtKB
Cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentTAS:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
LearningIEA:Ensembl
Locomotory behaviorIEA:Ensembl
MemoryIEA:Ensembl
Negative regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell growthManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Mitochondrion
Cytoplasm
Nucleus
Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
PTM
Autophosphorylated when activated by CDC42/p21.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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