Mouse Anti-PAK5 Recombinant Antibody (CBYC-P148) (CBMAB-P0708-YC)

Name: Mouse Anti-PAK5 Recombinant Antibody (CBYC-P148)
SKU: CBMAB-P0708-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-P148

Application

WB, IHC

Immunogen

E. coli-derived Recombinant human PAK7, Met1-Glu134

Specificity

Human, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS with trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

P21 (RAC1) Activated Kinase 5

Introduction

PAK5 (P21 (RAC1) Activated Kinase 5) is a protein coding gene. Among its related pathways are Focal Adhesion and T cell receptor signaling pathway. An important paralog of the gene is PAK4.

Entrez Gene ID

Human	57144
Rat	311450

UniProt ID

Human	Q9P286
Rat	D4A280

Alternative Names

PAK7

Function

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Cell migrationManual Assertion Based On ExperimentTAS:UniProtKB
Cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentTAS:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
LearningIEA:Ensembl
Locomotory behaviorIEA:Ensembl
MemoryIEA:Ensembl
Negative regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell growthManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Mitochondrion
Cytoplasm
Nucleus
Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

PTM

Autophosphorylated when activated by CDC42/p21.

Zhang, K., Wang, Y., Fan, T., Zeng, C., & Sun, Z. S. (2022). The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders. Protein & cell, 13(1), 6-25.

Chetty, A. K., Ha, B. H., & Boggon, T. J. (2022). Rho family GTPase signaling through type II p21-activated kinases. Cellular and Molecular Life Sciences, 79(12), 598.

Wu, A., & Jiang, X. (2022). p21-Activated kinases as promising therapeutic targets in hematological malignancies. Leukemia, 36(2), 315-326.

Rane, C. K., & Minden, A. (2019, February). P21 activated kinase signaling in cancer. In Seminars in cancer biology (Vol. 54, pp. 40-49). Academic Press.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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