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Mouse Anti-PAPSS1 Recombinant Antibody (1F4) (CBMAB-P0761-YC)

Provided herein is a Mouse monoclonal antibody against Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1. The antibody can be used for immunoassay techniques, such as ELISA, IF, RNAi, WB.
See all PAPSS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F4
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, RNAi, WB

Basic Information

Immunogen
PAPSS1 (NP_005434, 144-252 aa) partial recombinant protein with GST tag. Immunogen sequence: QIHEGASLPF FEVFVDAPLH VCEQRDVKGL YKKARAGEIK GFTGIDSEYE KPEAPELVLK TDSCDVNDCV QQVVELLQER DIVPVDASYE VKELYVPENK LHLAKTDAE
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 144-252

Target

Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 1
Introduction
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.
Entrez Gene ID
9061
UniProt ID
O43252
Alternative Names
3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1; 3-Phosphoadenosine 5-Phosphosulfate Synthase 1; Sulfate Adenylyltransferase; Adenylyl-Sulfate Kinase; Sulfurylase Kinase 1; PAPS Synthase 1; PAPSS 1; ATPSK1;
Function
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722).
Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487).
Biological Process
3'-phosphoadenosine 5'-phosphosulfate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Sulfate assimilationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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