Mouse Anti-PAQR5 Recombinant Antibody (CBYC-P162) (CBMAB-P0767-YC)

Provided herein is a Mouse monoclonal antibody against Human Progestin And AdipoQ Receptor Family Member 5. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PAQR5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYC-P162

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

progestin and adipoQ receptor family member V

Introduction

PAQR5 has biased expression in kidney (RPKM 13.9), adrenal (RPKM 5.4) and 9 other tissues.

Entrez Gene ID

54852

UniProt ID

Q9NXK6

Alternative Names

MPRG

Function

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432).
Seems to act through a G(i) mediated pathway (PubMed:23763432).
May be involved in oocyte maturation (PubMed:12601167).

Biological Process

OogenesisIEA:UniProtKB-KW

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-51
Helical: 52-72
Extracellular: 73-80
Helical: 81-101
Cytoplasmic: 102-113
Helical: 114-134
Extracellular: 135-141
Helical: 142-162
Cytoplasmic: 163-186
Helical: 187-207
Extracellular: 208-253
Helical: 254-274
Cytoplasmic: 275-294
Helical: 295-315
Extracellular: 316-330

References

Wang, L., Yue, Y., Zhang, L., Jing, M., Ma, M., Liu, C., ... & Zhang, M. (2023). PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway. Cellular Oncology, 46(5), 1317-1332.

Abramicheva, P. A., Semenovich, D. S., Zorova, L. D., Pevzner, I. B., Sokolov, I. A., Popkov, V. A., ... & Plotnikov, E. Y. (2023). Decreased renal expression of PAQR5 is associated with the absence of a nephroprotective effect of progesterone in a rat UUO model. Scientific Reports, 13(1), 12871.

Tao, C., Liu, W., Yan, X., Yang, M., Yao, S., Shu, Q., ... & Zhu, R. (2022). PAQR5 expression is suppressed by TGFβ1 and associated with a poor survival outcome in renal clear cell carcinoma. Frontiers in Oncology, 11, 827344.

Lu, T., Xu, H. R., Dong, W., & Dong, H. (2022). Expression and prognosis analysis of PAQR5 in kidney cancer. Frontiers in Oncology, 12, 955510.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-PAQR5 Recombinant Antibody (CBFYM-3043)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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