Mouse Anti-PATZ1 Recombinant Antibody (CBWJZ-186) (CBMAB-Z0467-WJ)

Name: Mouse Anti-PATZ1 Recombinant Antibody (CBWJZ-186)
SKU: CBMAB-Z0467-WJ
Rating: 5 (1 reviews)

See all PATZ1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJZ-186

Application

ELISA, WB

Immunogen

PATZ1 (AA260-358) partial recombinant protein with GST tag. Immunogen sequence: PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS RTRKQVACE

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

POZ (BTB) and AT hook containing zinc finger 1

Introduction

PATZ1 (POZ/BTB And AT Hook Containing Zinc Finger 1) is a Protein Coding gene. Diseases associated with PATZ1 include Sarcoma. Among its related pathways are Coregulation of Androgen receptor activity and Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is MAZ.

Entrez Gene ID

23598

UniProt ID

Q9HBE1

Alternative Names

ZSG; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; dJ400N23

Function

Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552).
Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280).
Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552).
(Microbial infection) Plays a positive role in viral cDNA synthesis.

Biological Process

Male gonad developmentIEA:Ensembl
Negative regulation of endothelial cell migrationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
SpermatogenesisIEA:Ensembl
T cell differentiationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.

Kim, H., Lee, K., Phi, J. H., Paek, S. H., Yun, H., Choi, S. H., & Park, S. H. (2023). Neuroepithelial tumor with EWSR1:: PATZ1 fusion: A literature review. Journal of Neuropathology & Experimental Neurology, 82(11), 934-947.

Lucà, S., Franco, R., Napolitano, A., Soria, V., Ronchi, A., Zito Marino, F., ... & Fedele, M. (2023). PATZ1 in non-small cell lung cancer: a new biomarker that negatively correlates with PD-L1 expression and suppresses the malignant phenotype. Cancers, 15(7), 2190.

Mancinelli, S., Vitiello, M., Donnini, M., Mantile, F., Palma, G., Luciano, A., ... & Fedele, M. (2021). The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation. Frontiers in Cell and Developmental Biology, 9, 657149.

Alhalabi, K. T., Stichel, D., Sievers, P., Peterziel, H., Sommerkamp, A. C., Sturm, D., ... & Jones, D. T. (2021). PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta neuropathologica, 142(5), 841-857.

Al-Obaidy, K. I., Bridge, J. A., Cheng, L., Sumegi, J., Reuter, V. E., Benayed, R., ... & Grignon, D. J. (2021). EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma. Modern Pathology, 34(10), 1921-1934.

Park, K. W., Cai, Y., Benjamin, T., Qorbani, A., & George, J. (2020). Round cell sarcoma with EWSR1‐PATZ1 gene fusion in the neck: Case report and review of the literature. The Laryngoscope, 130(12), E833-E836.

Chougule, A., Taylor, M. S., Nardi, V., Chebib, I., Cote, G. M., Choy, E., ... & Deshpande, V. (2019). Spindle and round cell sarcoma with EWSR1-PATZ1 gene fusion: a sarcoma with polyphenotypic differentiation. The American journal of surgical pathology, 43(2), 220-228.

Siegfried, A., Rousseau, A., Maurage, C. A., Pericart, S., Nicaise, Y., Escudie, F., ... & Uro‐Coste, E. (2019). EWSR1‐PATZ1 gene fusion may define a new glioneuronal tumor entity. Brain Pathology, 29(1), 53-62.

Bridge, J. A., Sumegi, J., Druta, M., Bui, M. M., Henderson-Jackson, E., Linos, K., ... & Brohl, A. S. (2019). Clinical, pathological, and genomic features of EWSR1-PATZ1 fusion sarcoma. Modern Pathology, 32(11), 1593-1604.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PATZ1 Recombinant Antibody (CBWJZ-186)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PATZ1 Recombinant Antibody (D-5) (CAT#: CBMAB-P0848-YC)

Mouse Anti-PATZ1 Recombinant Antibody (8D6) (CAT#: CBMAB-P0847-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry