Mouse Anti-PAX1 Recombinant Antibody (5A10D9) (CBMAB-P0854-YC)

Name: Mouse Anti-PAX1 Recombinant Antibody (5A10D9)
SKU: CBMAB-P0854-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5A10D9

Application

ELISA, WB

Specificity

Human, Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Paired Box 1

Introduction

PAX1 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations.

Entrez Gene ID

Human	5075
Mouse	18503

UniProt ID

Human	P15863
Mouse	P09084

Alternative Names

Paired Box 1; Paired Box Gene 1; HUP48; Paired Box Protein Pax-1; Paired Domain Gene HuP48; OFC2;

Function

This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).

Biological Process

Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

Involvement in disease

Otofaciocervical syndrome 2, with T-cell deficiency (OTFCS2):
An autosomal recessive disorder characterized by facial dysmorphism, cup-shaped low-set ears, preauricular fistulas, hearing loss, branchial defects, skeletal anomalies including vertebral defects, low-set clavicles, winged scapulae, sloping shoulders, and mild intellectual disability. Some patients also exhibit altered thymus development with T-cell immunodeficiency.

Pedrosa, A. E., de Azevedo, G. B. L., Cardoso, J. V., Guimarães, J. A. M., Defino, H. L. A., & Perini, J. A. (2022). Polymorphisms in paired box 1 gene were associated with susceptibility of adolescent idiopathic scoliosis: A case–control study. Journal of Craniovertebral Junction and Spine, 13(3), 318-324.

Wu, W., Kong, X., Jia, Y., Jia, Y., Ou, W., Dai, C., ... & Gao, R. (2022). An overview of PAX1: expression, function and regulation in development and diseases. Frontiers in Cell and Developmental Biology, 10, 1051102.

Yamazaki, Y., Urrutia, R., Franco, L. M., Giliani, S., Zhang, K., Alazami, A. M., ... & Notarangelo, L. D. (2020). PAX1 is essential for development and function of the human thymus. Science Immunology, 5(44), eaax1036.

Fang, C., Wang, S. Y., Liou, Y. L., Chen, M. H., Ouyang, W., & Duan, K. M. (2019). The promising role of PAX1 (aliases: HUP48, OFC2) gene methylation in cancer screening. Molecular Genetics & Genomic Medicine, 7(3), e506.

Su, P. H., Lai, H. C., Huang, R. L., Chen, L. Y., Wang, Y. C., Wu, T. I., ... & Chang, C. C. (2019). Paired box-1 (PAX1) activates multiple phosphatases and inhibits kinase cascades in cervical cancer. Scientific reports, 9(1), 9195.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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