Mouse Anti-PAX9 Recombinant Antibody (3B8) (CBMAB-P0903-YC)

Name: Mouse Anti-PAX9 Recombinant Antibody (3B8)
SKU: CBMAB-P0903-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3B8

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Paired Box 9

Introduction

PAX9 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3.

Entrez Gene ID

5083

UniProt ID

P55771

Alternative Names

Paired Box 9; Paired Box Protein Pax-9; Paired Domain Gene 9; Paired Box Gene 9; STHAG3;

Function

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

Biological Process

Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to growth factor stimulusIEA:Ensembl
Endoderm developmentIEA:Ensembl
Face morphogenesisIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
OdontogenesisIEA:Ensembl
Regulation of odontogenesisIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Tooth agenesis, selective, 3 (STHAG3):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).

Hayashi, T., Kishi, M., Takamochi, K., Hosoya, M., Kohsaka, S., Kishikawa, S., ... & Tokyo Metropolitan Innovative Oncology Research Group (TMIG). (2023). Expression of paired box 9 defines an aggressive subset of lung adenocarcinoma preferentially occurring in smokers. Histopathology, 82(5), 672-683.

Chen, X., Li, Y., Paiboonrungruang, C., Li, Y., Peters, H., Kist, R., & Xiong, Z. (2022). PAX9 in cancer development. International Journal of Molecular Sciences, 23(10), 5589.

Zhao, Z., Szczepanski, A. P., Tsuboyama, N., Abdala-Valencia, H., Goo, Y. A., Singer, B. D., ... & Wang, L. (2021). PAX9 determines epigenetic state transition and cell fate in cancer. Cancer research, 81(18), 4696-4708.

Bhol, C. S., Patil, S., Sahu, B. B., Patra, S. K., & Bhutia, S. K. (2021). The clinical significance and correlative signaling pathways of paired box gene 9 in development and carcinogenesis. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188561.

Sun, K., Yu, M., Yeh, I., Zhang, L., Liu, H., Cai, T., ... & Han, D. (2021). Functional study of novel PAX9 variants: The paired domain and non‐syndromic oligodontia. Oral Diseases, 27(6), 1468-1477.

Farley-Barnes, K. I., Deniz, E., Overton, M. M., Khokha, M. K., & Baserga, S. J. (2020). Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development. PLoS Genetics, 16(8), e1008967.

Xu, J., Zhang, Y., You, S., Guo, Y., Chen, S., Chang, Y., ... & Sun, Y. (2020). Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog. Life Sciences, 257, 118053.

Yang, C. W., Shi, J. Y., Yin, B., Shi, B., & Jia, Z. L. (2020). Mutation at Paired box gene 9 is associated with non-syndromic cleft lip only from Western Han Chinese population. Archives of Oral Biology, 117, 104829.

Li, R., Chen, Z., Yu, Q., Weng, M., & Chen, Z. (2019). The function and regulatory network of Pax9 gene in palate development. Journal of dental research, 98(3), 277-287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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