Mouse Anti-PBX2 Recombinant Antibody (CBYC-P191) (CBMAB-P0933-YC)

Name: Mouse Anti-PBX2 Recombinant Antibody (CBYC-P191)
SKU: CBMAB-P0933-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-P191

Application

WB, RNAi, ELISA, WB, IF

Immunogen

PBX2 (NP_002577, 354-430 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PBX2

Introduction

PBX2 is a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.

Entrez Gene ID

5089

UniProt ID

P40425

Alternative Names

G17; PBX2MHC; HOX12

Function

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Embryonic limb morphogenesisIEA:Ensembl
Embryonic organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Eye developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Proximal/distal pattern formationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Zhang, J., Chen, B., Wang, Y., Liu, X., Yan, H., Wong, K. Y., ... & Kang, W. (2023). The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer. The Journal of Pathology, 260(4), 402-416.

Wada, R., Fujinuma, S., Nakatsumi, H., Matsumoto, M., & Nakayama, K. I. (2023). Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1. The Journal of Biochemistry, 173(2), 129-138.

Lin, J., Zhu, H., Hong, L., Tang, W., Wang, J., Hu, H., ... & Liu, S. (2021). Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer. Aging (Albany NY), 13(5), 6606.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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