Mouse Anti-PBX3 Recombinant Antibody (1A11) (CBMAB-P0934-YC)

Name: Mouse Anti-PBX3 Recombinant Antibody (1A11)
SKU: CBMAB-P0934-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A11

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PBX Homeobox 3

Introduction

PBX3 has ubiquitous expression in adrenal (RPKM 28.9), ovary (RPKM 26.1) and 25 other tissues.

Entrez Gene ID

5090

UniProt ID

P40426

Alternative Names

PBX Homeobox 3; Pre-B-Cell Leukemia Transcription Factor 3; Pre-B-Cell Leukemia Homeobox 3; Homeobox Protein PBX3;

Function

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.

Biological Process

Adult locomotory behaviorIEA:Ensembl
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Anterior compartment pattern formationManual Assertion Based On ExperimentTAS:ProtInc
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Dorsal spinal cord developmentIEA:Ensembl
Embryonic organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Eye developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron developmentManual Assertion Based On ExperimentIBA:GO_Central
Posterior compartment specificationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of respiratory gaseous exchange by nervous system processIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Respiratory gaseous exchange by respiratory systemIEA:Ensembl

Cellular Location

Nucleus

Luo, X., Wei, M., Li, W., Zhao, H., Kasim, V., & Wu, S. (2023). PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression. International Journal of Biological Sciences, 19(14), 4525.

Liu, Y., Song, J., Zhang, H., Liao, Z., Liu, F., Su, C., ... & Chen, X. (2022). EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 164.

Zhuang, Q., Jin, Z., Zheng, X., Jin, T., & Xiang, L. (2021). Long non‑coding RNA LINC00460 serves as a potential biomarker and oncogene via regulation of the miR‑320b/PBX3 axis in acute myeloid leukemia. Molecular Medicine Reports, 23(6), 1-12.

Li, W. F., Herkilini, A., Tang, Y., Huang, P., Song, G. B., Miyagishi, M., ... & Wu, S. R. (2021). The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53. Acta Pharmacologica Sinica, 42(11), 1888-1899.

Zhang, Y., Guo, H., & Zhang, H. (2021). SNHG10/DDX54/PBX3 feedback loop contributes to gastric cancer cell growth. Digestive Diseases and Sciences, 66, 1875-1884.

Morgan, R., & Pandha, H. S. (2020). PBX3 in Cancer. Cancers, 12(2), 431.

Li, Y. S., Zou, Y., & Dai, D. Q. (2019). MicroRNA-320a suppresses tumor progression by targeting PBX3 in gastric cancer and is downregulated by DNA methylation. World Journal of Gastrointestinal Oncology, 11(10), 842.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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