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Mouse Anti-PCDH11Y Recombinant Antibody (7D12) (CBMAB-P0965-YC)

Provided herein is a Mouse monoclonal antibody against Human Protocadherin 11 Y-Linked. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PCDH11Y antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7D12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PCDH11Y (-, 57-166 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protocadherin 11 Y-linked
Introduction
PCDH11Y belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system.
Entrez Gene ID
83259
UniProt ID
Q9BZA8
Alternative Names
Protocadherin 11 Y-Linked; Protocadherin On The Y Chromosome; Protocadherin Prostate Cancer; Protocadherin 22; Protocadherin-PC; PCDH22; PCDHY; Protocadherin-11 Y-Linked;
Function
Potential calcium-dependent cell-adhesion protein.
Biological Process
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Positive regulation of Wnt signaling pathwayIMP:UniProtKB
SpermatogenesisIMP:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.
Topology
Extracellular: 29-844
Helical: 845-865
Cytoplasmic: 866-1340
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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