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Rat Anti-PCDH12 Recombinant Antibody (RM0509-19R9) (CBMAB-1658-CN)

This product is a rat antibody that recognizes PCDH12 of mouse. The antibody RM0509-19R9 can be used for immunoassay techniques such as: WB.
See all PCDH12 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
RM0509-19R9
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant fragment corresponding to Mouse PCDH12 aa. 1-716.
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protocadherin 12
Introduction
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. It is unable to bind to catenins, weakly associates with the cytoskeleton.
Entrez Gene ID
53601
UniProt ID
O55134
Alternative Names
Pcdh14; VE-cad-2
Function
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity).
Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705).
Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity).
Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).
Biological Process
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesIEA:Ensembl
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Glycogen metabolic processIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:Ensembl
Labyrinthine layer developmentIEA:Ensembl
Neuron recognitionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Protocadherin-12
Cell membrane
Cell junction
Protocadherin-12, secreted form
Secreted
The secreted form is produced following cleavage by ADAM10.
Involvement in disease
Diencephalic-mesencephalic junction dysplasia syndrome 1 (DMJDS1):
An autosomal recessive syndrome characterized by severe global developmental delay with profound intellectual disability, spasticity or dystonia, and congenital microcephaly. Brain imaging shows hypothalamic midbrain dysplasia, diencephalic-mesencephalic dysplasia, and intracerebral calcifications.
Topology
Extracellular: 25-718
Helical: 719-739
Cytoplasmic: 740-1184
PTM
Protocadherin-12
Cleaved by ADAM10 close to the transmembrane domain to release the Protocadherin-12, secreted form in the serum. Cleavage results in reduced cellular adhesion in a cell migration assay.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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