Mouse Anti-PCDH7 Recombinant Antibody (2G6) (CBMAB-P0975-YC)

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Basic Information

Host Animal
Mouse
Clone
2G6
Application
LMNX
Immunogen
Full length human recombinant protein of human PCDH7 (NM_032457) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
protocadherin 7
Introduction
PCDH7 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.
Entrez Gene ID
UniProt ID
Alternative Names
Protocadherin 7; Protein Phosphatase 1, Regulatory Subunit 120; BH-Protocadherin (Brain-Heart); Brain-Heart Protocadherin; BH-Pcdh; BHPCDH; Protocadherin-7; PPP1R120;
Biological Process
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 29-879
Helical: 880-900
Cytoplasmic: 901-1069

Xiao, Y., Hu, M., Lin, Q., Zhang, T., Li, S., Shu, L., ... & Mo, X. (2023). Dopey2 and Pcdh7 orchestrate the development of embryonic neural stem cells/progenitors in zebrafish. Iscience, 26(3).

Wang, Y., Zhang, Y., Su, X., Qiu, Q., Yuan, Y., Weng, C., ... & Lin, W. (2022). Circular RNA circDVL1 inhibits clear cell renal cell carcinoma progression through the miR-412-3p/PCDH7 axis. International Journal of Biological Sciences, 18(4), 1491.

Liu, Z., Xu, Y., Liu, X., & Wang, B. (2022). PCDH7 knockdown potentiates colon cancer cells to chemotherapy via inducing ferroptosis and changes in autophagy through restraining MEK1/2/ERK/c-Fos axis. Biochemistry and Cell Biology, 100(6), 445-457.

Zhang, S., & Fu, X. (2021). The clinical significance and biological function of PCDH7 in cervical cancer. Cancer Management and Research, 3841-3847.

Xu, S., Wu, X., Tao, Z., Li, H., Fan, C., Chen, S., ... & Hu, X. (2020). Effect of aberrantly methylated androgen receptor target gene PCDH7 on the development of androgen-independent prostate cancer cells. Genes & genomics, 42, 299-307.

Wang, C., Chen, A., Ruan, B., Niu, Z., Su, Y., Qin, H., ... & Sun, Q. (2020). PCDH7 inhibits the formation of homotypic cell-in-cell structure. Frontiers in cell and developmental biology, 8, 329.

Wang, Y., Kerrisk Campbell, M., Tom, I., Foreman, O., Hanson, J. E., & Sheng, M. (2020). PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function. Scientific Reports, 10(1), 10951.

Zhou, X., Padanad, M. S., Evers, B. M., Smith, B., Novaresi, N., Suresh, S., ... & O'Donnell, K. A. (2019). Modulation of mutant KrasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function. Molecular Cancer Research, 17(2), 594-603.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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