Sign in or Register   Sign in or Register
  |  

Mouse Anti-PCDHB14 Recombinant Antibody (5F7) (CBMAB-P1006-YC)

Provided herein is a Mouse monoclonal antibody against Human Protocadherin Beta 14. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PCDHB14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5F7
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PCDHB14 (NP_061757, 181-279 aa) partial recombinant protein with GST tag. Immunogen sequence: KIPDSSDRKI YPELVLDRAL DYEQEAELRL TLTAVDGGSP PKSGTTLVLI KVLDINDNAP EFPQSLYEVQ VPEDRPLGSW IATISAKDLD AGNYGKISY
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 181-279

Target

Full Name
protocadherin beta 14
Introduction
PCDHB14 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Entrez Gene ID
56122
UniProt ID
Q9Y5E9
Alternative Names
Protocadherin Beta 14; Protocadherin Beta-14; PCDH-Beta-14; PCDH-BETA14;
Function
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Biological Process
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules1 PublicationNAS:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 27-686
Helical: 687-711
Cytoplasmic: 712-798
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PCDHB14 Recombinant Antibody (5F7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare