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Mouse Anti-PCDHB15 Recombinant Antibody (9G429) (CBMAB-P1008-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9G429
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Partial Recombinant human Protocadherin beta-15 (207-306) with a GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protocadherin beta 15
Introduction
PCDHB15 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Entrez Gene ID
56121
UniProt ID
Q9Y5E8
Alternative Names
Protocadherin Beta 15; Protocadherin Beta-15; PCDH-Beta-15; PCDH-BETA15;
Function
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Biological Process
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 27-690
Helical: 691-711
Cytoplasmic: 712-787
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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