Mouse Anti-PCDHGC3 Recombinant Antibody (1C4) (CBMAB-P1029-YC)

Name: Mouse Anti-PCDHGC3 Recombinant Antibody (1C4)
SKU: CBMAB-P1029-YC
Rating: 5 (1 reviews)

See all PCDHGC3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C4

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protocadherin gamma subfamily C, 3

Introduction

PCDHGC3 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Entrez Gene ID

5098

UniProt ID

Q9UN70

Alternative Names

Protocadherin Gamma Subfamily C, 3; Protocadherin 43; Cadherin-Like 2; Protocadherin-2; PCDH-GAMMA-C3; PCDH2;

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Biological Process

Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules1 PublicationNAS:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Negative regulation of neuron apoptotic processIEA:Ensembl
Synapse organizationIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 32-693
Helical: 694-714
Cytoplasmic: 715-934

Cubiella, T., Celada, L., San‐Juan‐Guardado, J., Rodríguez‐Aguilar, R., Suárez‐Priede, Á., Poch, M., ... & Chiara, M. D. (2024). PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas. The Journal of Pathology.

Feldheim, J., Wend, D., Lauer, M. J., Monoranu, C. M., Glas, M., Kleinschnitz, C., ... & Burek, M. (2022). Protocadherin Gamma C3 (PCDHGC3) is strongly expressed in glioblastoma and its high expression is associated with longer progression-free survival of patients. International Journal of Molecular Sciences, 23(15), 8101.

Bernardo-Castiñeira, C., Valdes, N., Celada, L., Martinez, A. S. J., Sáenz-de-Santa-María, I., Bayón, G. F., ... & Chiara, M. D. (2019). Epigenetic deregulation of protocadherin PCDHGC3 in pheochromocytomas/paragangliomas associated with SDHB mutations. The Journal of Clinical Endocrinology & Metabolism, 104(11), 5673-5692.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PCDHGC3 Recombinant Antibody (1C4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PCDHGC3 Recombinant Antibody (S174B-27) (CAT#: CBMAB-P1032-YC)

Mouse Anti-PCDHGC3 Recombinant Antibody (CBYC-P212) (CAT#: CBMAB-P1031-YC)

Mouse Anti-PCDHGC3 Recombinant Antibody (3F10) (CAT#: CBMAB-A6451-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry