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Mouse Anti-PCGF3 Recombinant Antibody (1F1) (CBMAB-P1043-YC)

Provided herein is a Mouse monoclonal antibody against Human Polycomb Group Ring Finger 3. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P.
See all PCGF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F1
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P

Basic Information

Immunogen
PCGF3 (NP_006306, 133-242 aa) partial recombinant protein with GST tag. Immunogen sequence: SNKEAAEEKP EEDNDYHRSD EQVSICLECN SSKLRGLKRK WIRCSAQATV LHLKKFIAKK LNLSSFNELD ILCNEEILGK DHTLKFVVVT RWRFKKAPLL LHYRPKMDLL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 133-242

Target

Full Name
PCGF3
Introduction
PCGF3 contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined.
Entrez Gene ID
10336
UniProt ID
Q3KNV8
Alternative Names
Polycomb Group Ring Finger 3; RING Finger Protein 3A; Ring Finger Protein 3; RNF3A; RNF3; Polycomb Group RING Finger Protein 3; DONG1;
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).
Biological Process
Histone H2A-K119 monoubiquitinationISS:UniProtKB
Inactivation of X chromosome by genomic imprintingISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, nucleoplasm
Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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