Mouse Anti-PCSK4 Recombinant Antibody (CBXF-3285) (CBMAB-F3979-CQ)

Name: Mouse Anti-PCSK4 Recombinant Antibody (CBXF-3285)
SKU: CBMAB-F3979-CQ
Rating: 5 (1 reviews)

See all PCSK4 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3285

Application

ICC, IP, WB

Immunogen

Recombinant human furin

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proprotein Convertase Subtilisin/Kexin Type 4

Introduction

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II.

Entrez Gene ID

Human	54760
Mouse	18551

UniProt ID

Human	Q6UW60
Mouse	P29121

Alternative Names

Proprotein Convertase Subtilisin/Kexin Type 4; PC4; Testicular Tissue Protein Li 135; Proprotein Convertase 4; EC 3.4.21.75; EC 3.4.21.93; EC 3.4.21.-; EC 3.4.21; SPC5;

Function

Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity).
In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity).
Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806).
May also participate in folliculogenesis in the ovaries (By similarity).

Biological Process

Acrosome reactionISS:UniProtKB
Binding of sperm to zona pellucidaISS:UniProtKB
FertilizationISS:UniProtKB
Peptide hormone processingManual Assertion Based On ExperimentIBA:GO_Central
Protein processingManual Assertion Based On ExperimentIDA:UniProtKB
Reproductive processISS:UniProtKB
Sperm capacitationISS:UniProtKB

Cellular Location

Membrane
Cytoplasmic vesicle, secretory vesicle, acrosome membrane

Topology

Helical: 709-729

PTM

N-glycosylated.
Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain.

Dahril, D., & Nugroho, W. (2019). Human Contraceptives: Current Status, Sperm Antigen Inhibitors and an Insight into PCSK4. In Innovations In Assisted Reproduction Technology. IntechOpen.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PCSK4 Recombinant Antibody (CBXF-3285)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry