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Mouse Anti-PCSK4 Recombinant Antibody (CBXF-3285) (CBMAB-F3979-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXF-3285
Antibody Isotype
IgG2a
Application
ICC, IP, WB

Basic Information

Immunogen
Recombinant human furin
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proprotein Convertase Subtilisin/Kexin Type 4
Introduction
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II.
Entrez Gene ID
Human54760
Mouse18551
UniProt ID
HumanQ6UW60
MouseP29121
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 4; PC4; Testicular Tissue Protein Li 135; Proprotein Convertase 4; EC 3.4.21.75; EC 3.4.21.93; EC 3.4.21.-; EC 3.4.21; SPC5;
Function
Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity).
In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity).
Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806).
May also participate in folliculogenesis in the ovaries (By similarity).
Biological Process
Acrosome reactionISS:UniProtKB
Binding of sperm to zona pellucidaISS:UniProtKB
FertilizationISS:UniProtKB
Peptide hormone processingManual Assertion Based On ExperimentIBA:GO_Central
Protein processingManual Assertion Based On ExperimentIDA:UniProtKB
Reproductive processISS:UniProtKB
Sperm capacitationISS:UniProtKB
Cellular Location
Membrane
Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Topology
Helical: 709-729
PTM
N-glycosylated.
Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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