Sign in or Register   Sign in or Register
  |  

Rabbit Anti-PCYT1A Recombinant Antibody (BA0248) (CBMAB-0609CQ)

This product is a rabbit antibody that recognizes PCYT1A. The antibody BA0248 can be used for immunoassay techniques such as: ICC, IHC-P, WB.
See all PCYT1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
BA0248
Antibody Isotype
IgG
Application
ICC, IHC-P, WB

Basic Information

Immunogen
Human PCYT1A aa 1-100
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphate cytidylyltransferase 1, choline, alpha
Introduction
This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Diseases associated with PCYT1A include Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy and Leber Congenital Amaurosis. Among its related pathways are Metabolism and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include protein homodimerization activity and choline-phosphate cytidylyltransferase activity. An important paralog of this gene is PCYT1B.
Entrez Gene ID
Human5130
Mouse13026
UniProt ID
HumanP49585
MouseP49586
Alternative Names
CT; CTA; CCTA; CTPCT; PCYT1; SMDCRD
Function
Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
Biological Process
CDP-choline pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylcholine biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Membrane
Endoplasmic reticulum
Nucleus
It can interconvert between an inactive cytosolic form and an active membrane-bound form.
Involvement in disease
Spondylometaphyseal dysplasia with cone-rod dystrophy (SMDCRD):
A disorder characterized by postnatal growth deficiency resulting in profound short stature, rhizomelia with bowing of the lower extremities, platyspondyly with anterior vertebral protrusions, progressive metaphyseal irregularity and cupping with shortened tubular bones, and early-onset progressive visual impairment associated with a pigmentary maculopathy and electroretinographic evidence of cone-rod dysfunction.
PTM
The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).
Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-PCYT1A Recombinant Antibody (BA0248)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare